TGF-beta1 modulates matrix metalloproteinase-13 expression in hepatic stellate cells by complex mechanisms involving p38MAPK, PI3-kinase, AKT, and p70S6k

American Journal of Physiology. Gastrointestinal and Liver Physiology
Carmen G LechugaMarcos Rojkind

Abstract

Transforming growth factor-beta1 (TGF-beta1), the main cytokine involved in liver fibrogenesis, induces expression of the type I collagen genes in hepatic stellate cells by a transcriptional mechanism, which is hydrogen peroxide and de novo protein synthesis dependent. Our recent studies have revealed that expression of type I collagen and matrix metalloproteinase-13 (MMP-13) mRNAs in hepatic stellate cells is reciprocally modulated. Because TGF-beta1 induces a transient elevation of alpha1(I) collagen mRNA, we investigated whether this cytokine was able to induce the expression of MMP-13 mRNA during the downfall of the alpha1(I) collagen mRNA. In the present study, we report that TGF-beta1 induces a rapid decline in steady-state levels of MMP-13 mRNA at the time that it induces the expression of alpha1(I) collagen mRNA. This change in MMP-13 mRNA expression occurs within the first 6 h postcytokine administration and is accompanied by a twofold increase in gene transcription and a fivefold decrease in mRNA half-life. This is followed by increased expression of MMP-13 mRNA, which reaches maximal values by 48 h. Our results also show that this TGF-beta1-mediated effect is de novo protein synthesis-dependent and requires the activ...Continue Reading

References

Jan 1, 1992·Pharmacology & Therapeutics·M Rojkind
Jan 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H M SandlerA S Lichter
Jun 30, 1988·The New England Journal of Medicine·D KershenobichM Rojkind
Mar 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·P Del Arenal, R Pérez-Tamayo
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·S NakanishiT Balla
Nov 10, 1994·The New England Journal of Medicine·W A Border, N A Noble
Dec 16, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T TakaharaA Watanabe
Oct 24, 1998·Biochemical and Biophysical Research Communications·Y InagakiP Greenwel
Nov 18, 1998·Current Opinion in Cell Biology·S D Shapiro
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E R García-TrevijanoM Rojkind
Jun 17, 1999·Alcoholism, Clinical and Experimental Research·M Rojkind
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R C BenyonM J Arthur
Nov 27, 1999·Science·S Zimmermann, K Moelling
May 4, 2000·The New England Journal of Medicine·G C BlobeH F Lodish
Jul 25, 2000·The Journal of Biological Chemistry·S J DengM L Moss
Aug 1, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·M J Arthur
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·J Massagué
Apr 20, 2001·Cytokine & Growth Factor Reviews·X LiuH F Lodish
Jan 12, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yoshiya TahashiKyoichi Inoue
Sep 14, 2002·Biopolymers·Janelle L Lauer-FieldsGregg B Fields
Jan 18, 2003·Current Gastroenterology Reports·Efsevia AlbanisScott L Friedman
May 22, 2003·The American Journal of Pathology·Benjamin SchaeferMarcos Rojkind
Jul 23, 2003·Digestive Diseases and Sciences·Asma ArifDaniel H Gregory
Jan 15, 2004·Current Gastroenterology Reports·Charles S Lieber
Jan 28, 2004·Human Pathology·Stanislas PolChristian Bréchot

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Citations

Mar 27, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ching-Hao LiJaw-Jou Kang
Jan 30, 2009·Journal of Gastroenterology and Hepatology·Yun-Lian LinYi-Tsau Huang
Mar 28, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Andrew D FrutkinDavid A Dichek
Sep 6, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shigeki TsukadaRichard A Rippe
Nov 12, 2016·Cold Spring Harbor Perspectives in Biology·Kunxin Luo
Dec 17, 2016·Molecular Nutrition & Food Research·Yan GengZheng-Hong Xu
Aug 12, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yuqing LiuHui Zhang
Jul 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hiroshi UchinamiJeanine D'Armiento
Aug 10, 2006·Journal of Cellular Physiology·María P Pérez de ObanosMaría J Iraburu
Feb 19, 2009·Journal of Viral Hepatitis·Nadia Alatrakchi, Margaret Koziel
Aug 8, 2009·International Journal of Experimental Pathology·Femke HeindryckxHans Van Vlierberghe
Aug 28, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hitoshi Yoshiji
Oct 9, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Liwen NiuQi Cao
Dec 7, 2005·International Journal of Cancer. Journal International Du Cancer·Su-Kyung LeeByoung-Mog Kwon
Sep 23, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Carmen G LechugaMarcos Rojkind
Jan 3, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Yuqing LiuTao Ye
Sep 13, 2018·Laboratory Investigation; a Journal of Technical Methods and Pathology·Zhuo WangHongmin Zhang
Nov 24, 2012·Physiological Research·A JiroutováJ Kanta
Apr 25, 2021·Experimental Eye Research·Steven E Wilson
Jul 28, 2005·Matrix Biology : Journal of the International Society for Matrix Biology·Carlos RossaKeith L Kirkwood
Nov 6, 2008·Clinics in Liver Disease·R UrtasunN Nieto
Oct 9, 2021·Frontiers in Cell and Developmental Biology·Xiaoyan WuXiaolei Shi

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