PMID: 11899912Mar 20, 2002Paper

TGF-beta3 in the treatment of pressure ulcers: a preliminary report

Advances in Skin & Wound Care
J HirshbergR S Rees

Abstract

To determine the safety, tolerability, and efficacy of TGF-beta3 in the treatment of chronic, nonhealing pressure ulcers. A subset analysis of data from a randomized, blind, parallel, placebo-controlled trial involving 270 patients. University of Michigan Wound Care Center. A total of 14 patients (6 women and 8 men aged > or = 18 years) with pressure ulcers were randomly assigned to 1 of 3 groups to receive once daily topical application of recombinant TGF-beta3 or placebo gel for a period of no more than 16 weeks. Group 1 (n=4) received 1.0 microg/cm2 of TGF-beta3, Group 2 (n=5) received 2.5 microg/cm2 of TGF-beta3, and Group 3 (n=5) received placebo gel. All subjects received standardized wound care as well. Weekly evaluations were performed for efficacy, determined by relative wound surface areas and volumes, and were compared with initial baseline values and safety parameters. Reduction in pressure ulcer area and volume. Group 2 had a significantly increased rate of wound healing at the fourth visit (P<.05). No significant difference was observed in the healing rate among the groups at the termination of the study. Treatment with TGF-beta3 was well tolerated and there were no significant adverse reactions. The findings of t...Continue Reading

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Citations

Mar 10, 2004·British Journal of Plastic Surgery·David ChinWilliam B Coman
Jul 11, 2006·Current Opinion in Pulmonary Medicine·Steven E MutsaersY C Gary Lee
Apr 15, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Xiaobing FuZhiyong Sheng
Mar 1, 2006·Expert Opinion on Emerging Drugs·Karen Meier, Lillian B Nanney
Jun 27, 2012·Clinics in Plastic Surgery·Elizabeth KiwanukaElof Eriksson
Jun 6, 2003·The Journal of Investigative Dermatology·Daisuke SawamuraHiroshi Shimizu
Oct 31, 2007·Clinics in Plastic Surgery·Paul J Leahy, W Thomas Lawrence
Oct 2, 2007·Journal of the American College of Surgeons·Athina TatsioniJoseph Lau
Nov 30, 2007·Dermatologic Therapy·Rahul C Mehta, Richard E Fitzpatrick
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Nov 26, 2018·Journal of the American Medical Directors Association·Luis Furuya-KanamoriLukman Thalib

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