TGFβ1 genetic variants are associated with an increased risk of acute brucellosis

Infectious Diseases
Adel SepanjniaFatemeh Dahmardeh

Abstract

Cytokines play a critical role in the regulation of the immune response against brucellosis infection, and mediate production of many pro- and anti-inflammatory signals. Transforming growth factor-beta 1 (TGFβ1), a powerful suppressive cytokine, inhibits macrophage activation and modulates T-cell function, and plays crucial roles in regulation of microbial replication and host responses to brucella. The association of three polymorphisms in the TGFβ1 gene (-509 C/T [rs1800469], + 868 C/T [rs1800470], and + 913 G/C [rs1800471]) in promoter, codons 10 and 25, respectively, with brucellosis infection was evaluated. This case-control study was performed on a total of 281 Iranian subjects including 153 patients with active brucellosis and 128 age- and sex-matched healthy individuals as controls. Genotyping for the TGFβ1 -509 C/T and + 868 C/T variants was performed using tetra amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR). Also, the + 913 G/C polymorphism was genotyped using an allele-specific PCR. The results demonstrated that the TGFβ1 + 868 C/T mutant homozygote genotype (TT vs CC), was a risk factor for developing brucellosis in the co-dominant and recessive models (odds ratio (OR) = 2.60, p = 0...Continue Reading

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Citations

Nov 21, 2015·Human Immunology·Ebrahim Eskandari-NasabAdel Sepanj-Nia
Apr 14, 2016·Revista Do Instituto De Medicina Tropical De São Paulo·Wilson DominguesThelma Suely Okay
Sep 21, 2017·International Journal of Immunogenetics·E EskandariE Pahlevani
Feb 19, 2019·Infectious Diseases·Omolbanin AmjadiAhmadreza Zarifian
Mar 15, 2016·Asian Pacific Journal of Tropical Medicine·Mehdi MoghadampourFatemeh Shabani
Jul 13, 2017·Revista Da Sociedade Brasileira De Medicina Tropical·Ebrahim EskandariTooba Nakhzari-Khodakheir

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