Abstract
Cytokines play a critical role in the regulation of the immune response against brucellosis infection, and mediate production of many pro- and anti-inflammatory signals. Transforming growth factor-beta 1 (TGFβ1), a powerful suppressive cytokine, inhibits macrophage activation and modulates T-cell function, and plays crucial roles in regulation of microbial replication and host responses to brucella. The association of three polymorphisms in the TGFβ1 gene (-509 C/T [rs1800469], + 868 C/T [rs1800470], and + 913 G/C [rs1800471]) in promoter, codons 10 and 25, respectively, with brucellosis infection was evaluated. This case-control study was performed on a total of 281 Iranian subjects including 153 patients with active brucellosis and 128 age- and sex-matched healthy individuals as controls. Genotyping for the TGFβ1 -509 C/T and + 868 C/T variants was performed using tetra amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR). Also, the + 913 G/C polymorphism was genotyped using an allele-specific PCR. The results demonstrated that the TGFβ1 + 868 C/T mutant homozygote genotype (TT vs CC), was a risk factor for developing brucellosis in the co-dominant and recessive models (odds ratio (OR) = 2.60, p = 0...Continue Reading
References
Dec 28, 1999·Microbes and Infection·S G Reed
Aug 10, 2001·The Journal of Allergy and Clinical Immunology·P D ArkwrightI V Hutchinson
Feb 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jinkyung KoGary A Splitter
Sep 17, 2003·Journal of Gastroenterology and Hepatology·Seiji SuzukiMasashi Mizokami
Dec 17, 2003·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·M J BravoA Caballero
Nov 16, 2004·Cellular Immunology·Ashlesh K MurthyBernard P Arulanandam
Mar 26, 2005·Immunology Letters·Gladys FiorenzaDiana G Dlugovitzky
Jan 21, 2006·World Journal of Gastroenterology : WJG·Zaigham AbbasWasim Jafri
Apr 20, 2006·Molecular Immunology·Annika RaitalaMikko Hurme
May 25, 2006·Bioinformatics·Xavier SoléVíctor Moreno
Dec 23, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A RafieiS A Alavi
Mar 16, 2007·Journal of Human Hypertension·M P S SieJ C M Witteman
Jun 5, 2007·Cytokine·Ferah BudakHaluk B Oral
Jun 28, 2007·Journal of Chemotherapy·G Pappas, Z A Memish
Sep 23, 2008·Cytokine·María José BravoAbelardo Caballero
Aug 12, 2009·Microbes and Infection·Mohamed G Elfaki, Abdullah A Al-Hokail
Apr 21, 2010·Infection and Immunity·Manuel Rodríguez-ZapataMelchor Alvarez-Mon
Aug 3, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Sudhir KumarD N Rao
Nov 15, 2011·Journal of Leukocyte Biology·M Victoria DelpinoGuillermo H Giambartolomei
May 5, 2012·FEMS Immunology and Medical Microbiology·Mariana C FerreroPablo C Baldi
Mar 1, 2011·Oncology Letters·Lixia XuPinjin Hu
Oct 12, 2012·Molecular Biology Reports·Ebrahim Eskandari-NasabMohsen Taheri
Dec 12, 2012·Biomarkers in Medicine·Mohammad HashemiGholamreza Bahari
Jan 29, 2013·Gene·Zahra HeidariMohammad Hashemi
Mar 19, 2013·Mediterranean Journal of Hematology and Infectious Diseases·Mohamed A El-KoumiSalha H Al-Zahrani
Apr 13, 2013·Scandinavian Journal of Immunology·E Eskandari-NasabH Pourmasoumi
Sep 17, 2013·Microbiology and Immunology·Ebrahim Eskandari-NasabMehran Ghazali-bina
Oct 23, 2013·PloS One·Singh PoojaRituraj Konwar
Citations
Feb 6, 2016·Immunological Investigations·Sima KazemiMohammad Yousef Alikhani
Nov 21, 2015·Human Immunology·Ebrahim Eskandari-NasabAdel Sepanj-Nia
May 14, 2016·Japanese Journal of Infectious Diseases·Ozgur GunalOzlem Sezer
Apr 14, 2016·Revista Do Instituto De Medicina Tropical De São Paulo·Wilson DominguesThelma Suely Okay
Sep 21, 2017·International Journal of Immunogenetics·E EskandariE Pahlevani
Feb 19, 2019·Infectious Diseases·Omolbanin AmjadiAhmadreza Zarifian
Mar 15, 2016·Asian Pacific Journal of Tropical Medicine·Mehdi MoghadampourFatemeh Shabani
Jul 13, 2017·Revista Da Sociedade Brasileira De Medicina Tropical·Ebrahim EskandariTooba Nakhzari-Khodakheir
Apr 2, 2020·BMC Medical Genetics·Xiaochun JinYoutao Zhang