TGFβ2 is a prognostic-related biomarker and correlated with immune infiltrates in gastric cancer.

Journal of Cellular and Molecular Medicine
Zunqiang XiaoQiuran Xu

Abstract

TGFβ2 is an essential regulator of immune cell functionality, but the mechanisms whereby it drives immune infiltration in gastric cancer remain uncertain. The Oncomine and Tumor Immunoassay Resource (TIMER) databases were used for assessing the expression of TGFβ2, after which TIMER was used to explore the relationship between TGFβ2 and tumour immune infiltration. Finally, we assessed how TGFβ2 expression correlated with the expression of a set of marker genes associated with immune infiltration using TIMER and GEPIA. We determined TGFβ2 expression to be significantly correlated with outcome in multiple types of cancer in the Cancer Genome Atlas (TCGA), with the effect being particularly pronounced in gastric cancer. Furthermore, elevated TGFβ2 expression was found to be significantly correlated with gastric cancer N staging, and with the expression of a variety of immune markers associated with particular immune cell subsets. These results indicate that TGFΒ2 is associated with patient outcome and tumour immune cell infiltration in multiple cancer types. This suggests that TGFβ2 is a key factor which governs immune cell recruitment to gastric cancer tumours, potentially playing a vital role in governing immune cell infiltratio...Continue Reading

References

Sep 7, 2000·Journal of the National Cancer Institute·M P de CaesteckerA B Roberts
Feb 15, 2001·Microscopy Research and Technique·C BeckD Rowley
Dec 21, 2004·Current Opinion in Oncology·Kurtis E Bachman, Ben Ho Park
Oct 13, 2006·Archivum Immunologiae Et Therapiae Experimentalis·Alessandro Poggi, Maria Raffaella Zocchi
Feb 3, 2007·The Journal of Surgical Research·Konstantinos VagenasAthanassios C Tsamandas
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Victoria C LiuChung Lee
Mar 16, 2007·Neoplasia : an International Journal for Oncology Research·Daniel R RhodesArul M Chinnaiyan
Apr 5, 2007·Cancer Cell International·S A Sharifah SakinahL P Azimahtol Hawariah
Jul 30, 2008·Cell·Joan Massagué
Aug 12, 2008·Cell·Ming O Li, Richard A Flavell
Dec 31, 2008·Cell Research·Marie-José GoumansPeter ten Dijke
Apr 28, 2009·BMC Medical Genomics·Hideaki MizunoAkinori Sarai
Feb 25, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christy RalphFiona C Thistlethwaite
Oct 1, 2010·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hanna Bessler, Meir Djaldetti
Jun 20, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Farhad AzimiJohn F Thompson
Sep 29, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anandi SawantSelvarangan Ponnazhagan
Apr 20, 2014·World Journal of Gastroenterology : WJG·Jing-Yu Deng, Han Liang
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Jun 2, 2015·The New England Journal of Medicine·Dung T LeLuis A Diaz
Nov 3, 2016·Breast Cancer Research and Treatment·András LánczkyBalázs Győrffy
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Mar 28, 2017·Archivum Immunologiae Et Therapiae Experimentalis·Dariusz WaniczekMałgorzata Muc-Wierzgoń
Apr 6, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Andrea RavelliDaniele Generali
Aug 2, 2017·BioMed Research International·Letizia ProcaccioSara Lonardi
Apr 28, 2018·International Journal of Molecular Sciences·Laia CajaIsabel Fabregat

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Software Mentioned

TIMER
STAD
GEPIA

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