PMID: 22892881Aug 16, 2012

TGFA/Taq I polymorphism and environmental factors in non-syndromic oral clefts in Southern Brazil

Brazilian Oral Research
L T SouzaTêmis Maria Félix

Abstract

We report a study of TGFA/ Taq I polymorphisms and environmental factors in non-syndromic oral cleft in Southern Brazil. Nonsyndromic cleft case-parent triads were recruited to participate. Clinical data was collected with an emphasis on tobacco and alcohol use during pregnancy. DNA was extracted from peripheral blood and TGFA/ Taq I polymorphisms were analyzed by PCR/RFLP with Taq I restriction enzyme. Association of clefts and TGFA/ Taq I polymorphisms was determined using a transmission disequilibrium test (TDT). Association of environmental factors, clefts, and genotypes was evaluated with Fisher's exact test. The minor allele frequency was 0.064. We found no evidence of association between TGFA/ Taq I polymorphisms and clefting (TDT p = 0.335). We also found no association between TGFA/ TaqI polymorphisms and environmental factors (alcohol and/or tobacco). Therefore, no evidence was found that TGFA/ Taq I polymorphisms play a role in clefting in this population. No evidence was found that tobacco or alcohol exposure during pregnancy was related to clefting, however a larger sample size is needed to confirm these results.

References

Jan 1, 1997·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Andrew C LidralW Magee
May 1, 1997·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·D F WyszynskiTerri H Beaty
Jul 31, 1998·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·G M ShawEdward J Lammer
Jun 30, 2000·American Journal of Human Genetics·J Alves-SilvaV F Prado
Nov 25, 2000·American Journal of Human Genetics·D R Carvalho-SilvaS D Pena
Jul 17, 2001·Annals of Epidemiology·Terri H BeatyIain McIntosh
Jun 30, 2004·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Maria Rita Passos-BuenoBelmino Araújo
Jan 13, 2005·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Joanna S ZeigerKung-Yee Liang
May 27, 2005·Current Opinion in Genetics & Development·Astanand Jugessur, Jeffrey C Murray
Apr 3, 2008·Birth Defects Research. Part C, Embryo Today : Reviews·Min ShiJeffrey C Murray
Aug 14, 2008·American Journal of Medical Genetics. Part a·Cécile ChevrierSylvaine Cordier
Sep 16, 2008·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Angela Ehlers BertojaWanyce Miriam Robinson
Jul 9, 2009·Oral Diseases·Astanand JugessurN Kilpatrick
Sep 15, 2009·Lancet·Peter A MosseyWilliam C Shaw

Citations

Feb 4, 2014·International Journal of Pediatric Otorhinolaryngology·Yu LinShijie Tang
Jul 24, 2013·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Somsri Wiwanitkit, Viroj Wiwanitkit
Jun 30, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jihong Du, Jianhua Deng
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Marcella MartinelliLuca Scapoli

Related Concepts

Cleft Lip
Cleft Palate, Isolated
Genetic Equilibrium
Genetic Polymorphism
Cigar smoker
Nested Polymerase Chain Reaction
Transforming Growth Factor alpha
Maternal Exposure
Taq Polymerase
Alleles

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