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TGF(beta) Mediated Structural Remodeling Facilitates Optic Fissure Fusion And The Necessity Of BMP Antagonism In This Process

bioRxiv

Apr 28, 2017

Max D. KnickmeyerStephan Heermann

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Abstract

The optic fissure is a transient gap in the developing vertebrate eye, which must be closed as development proceeds. A persisting optic fissure, coloboma, is a major cause for blindness in children. Multiple factors are genetically linked to coloboma formation. However, especially the p...read more

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TGF-Beta Receptor Signaling Pathway
Ligand Binding
BMP2 protein, human
GREM1 gene
Inactivation
Recombinant Transforming Growth Factor
Follistatin
Ligands
Gene Knockdown Techniques
GREM1 protein, human
5
1
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TGF(beta) Mediated Structural Remodeling Facilitates Optic Fissure Fusion And The Necessity Of BMP Antagonism In This Process

bioRxiv

Apr 28, 2017

Max D. KnickmeyerStephan Heermann

DOI: 10.1101/131599

Abstract

The optic fissure is a transient gap in the developing vertebrate eye, which must be closed as development proceeds. A persisting optic fissure, coloboma, is a major cause for blindness in children. Multiple factors are genetically linked to coloboma formation. However, especially the p...read more

Mentioned in this Paper

TGF-Beta Receptor Signaling Pathway
Ligand Binding
BMP2 protein, human
GREM1 gene
Inactivation
5
1

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