Abstract
Mast cells are potent effectors of the inflammatory response, playing an important role in atopy, bacterial immunity, and animal models of arthritis, multiple sclerosis, and heart disease. Hence controlling mast cell numbers and responsiveness is essential for preventing inflammatory disease. We demonstrate that the cytokine transforming growth factor (TGF) beta1 is a potent inducer of mast cell apoptosis, a finding that was consistent in cultured mouse bone marrow-derived mast cells, peritoneal mast cells, and human mast cells. Cell death appeared to be caused by TGF-mediated repression of interleukin-3 (IL-3) receptor expression and function, leading to mitochondrial damage and activation of an apoptotic cascade acting via p53 and caspases. Although IL-3 receptor expression was reduced within 1 day of TGFbeta1 stimulation, apoptosis required at least 3 days to occur. This delay in onset is postulated to allow protective mast cell effector functions, protecting the host from infection while preventing the establishment of chronic inflammation. Our data support the theory that TGFbeta1 is an inhibitor of mast cell survival. The widespread expression of TGFbeta1 offers this cytokine as an ideal candidate for control of mast cell...Continue Reading
References
Oct 22, 1992·Nature·M M ShullD Calvin
Jan 1, 1990·Annual Review of Cell Biology·J Massagué
May 23, 1998·Annual Review of Immunology·J J Letterio, A B Roberts
Apr 14, 1999·Cell Death and Differentiation·H K BojesG M Cohen
Mar 8, 2000·The Journal of Experimental Medicine·V H SecorM A Brown
Oct 18, 2000·The Journal of Experimental Medicine·C F YeatmanJ J Ryan
Mar 27, 2001·Blood·N KambeL B Schwartz
Jun 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K A LindstedtP T Kovanen
Oct 1, 1995·American Journal of Therapeutics·Ravi MalaviyaSoman N. Abraham
Sep 7, 2002·Science·David M LeeMichael B Brenner
Apr 26, 2003·Blood·Christopher P ShelburneJohn J Ryan
Jun 18, 2003·Cell·Yigong Shi, Joan Massagué
Nov 5, 2003·Nature Immunology·James B McLachlanSoman N Abraham
Jan 17, 2004·Experimental Hematology·Daniel P BaileyJohn J Ryan
May 8, 2004·Trends in Biochemical Sciences·Peter ten Dijke, Caroline S Hill
Jun 14, 2005·Gut·T GebhardtS C Bischoff
Aug 10, 2005·International Archives of Allergy and Immunology·Christopher L Kepley
Citations
Aug 20, 2009·Cardiology in Review·Konstantinos D RizasMartin D Tilson
Jul 2, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Sridurga Mithraprabhu, Kate L Loveland
Jun 21, 2014·Cellular Immunology·Travis W FaberJohn J Ryan
Jul 18, 2008·Critical Reviews in Oncology/hematology·Daliah Shoshana Tamar Galinsky, Hovav Nechushtan
Jan 14, 2009·Journal of Clinical Pharmacy and Therapeutics·H-J ParkH-S Park
Mar 27, 2010·International Journal of Pediatric Otorhinolaryngology·Beata Zelazowska-RutkowskaBozena Skotnicka
Nov 11, 2009·Immunology Letters·Alon Y Hershko, Juan Rivera
Jul 22, 2008·Otolaryngologia polska. The Polish otolaryngology·Beata Zelazowska-RutkowskaMałgorzata Mrugacz
Dec 7, 2007·The American Journal of Pathology·Eva M J PetersRalf Paus
Sep 4, 2007·Brain Research·Mona KhalilAnn-Judith Silverman
Oct 10, 2006·Veterinary Immunology and Immunopathology·Tzu-Yin Lin, Cheryl A London
Jun 24, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Victor S NdawJohn J Ryan
Jun 17, 2010·Clinical and Experimental Immunology·W ZhangH Zhou
Mar 23, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew R MaceyJohn J Ryan
Apr 25, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomonobu ItoAlasdair M Gilfillan
Sep 27, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Josephine FernandoJohn J Ryan
Nov 27, 2019·Cells·Ralf WeiskirchenMichael Huber
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wei ZhaoLawrence B Schwartz
Mar 1, 2018·Biochemistry. Biokhimii︠a︡·M A ChelombitkoO P Ilinskaya
Aug 1, 2009·Molecular Biology Reports·Chenxiong LiuYaojiong Wu
May 15, 2018·Frontiers in Immunology·Heather L CaslinJohn J Ryan
Dec 9, 2020·International Journal of Molecular Sciences·Steffen K Meurer, Ralf Weiskirchen
Jul 3, 2021·Cells·Zhongwei Zhang, Yosuke Kurashima