TGFbeta1 modulates the phenotype of Schwann cells at the transcriptional level

Molecular and Cellular Neurosciences
Rajeshwar AwatramaniS S Scherer

Abstract

We have examined the effects of transforming growth factor beta1 (TGFbeta1) on gene expression in cultured rat Schwann cells (SCs). TGFbeta1 decreased the steady-state mRNA levels of several genes that are expressed by myelinating SCs but had varied effects on the mRNA levels of NCAM, L1, GAP-43, and p75-genes that are expressed by denervated and nonmyelinating SCs. TGFbeta1 antagonized the effects of forskolin on the mRNA levels of the transcription factors Oct-6/tst-1/SCIP and Krox20. Transcriptional run-off analysis demonstrated that the effects of TGFbeta1 on gene expression occur at least in part at the level of transcription. Thus, TGFbeta1 suppresses the expression of genes that characterize the different phenotypes of SCs, and these changes occur at least in part at a transcriptional level.

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Citations

Feb 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Nam LeJeffrey Milbrandt
Nov 9, 2011·Molecular and Cellular Biology·Nolan G GokeyJohn Svaren
May 12, 2005·Developmental Neuroscience·Justin J DoreSusan J Birren
Feb 6, 2004·The Journal of Cell Biology·David B ParkinsonKristjan R Jessen
Mar 14, 2013·Journal of Neuropathology and Experimental Neurology·Rafael B PetitoEuzenir N Sarno
Aug 18, 2004·Neuron·Suzana AtanasoskiUeli Suter
Aug 21, 2009·Journal of the Peripheral Nervous System : JPNS·Wagner Baetas-da-CruzLeny A Cavalcante
Aug 7, 2009·Cell and Tissue Research·Matthias KirschHans-Dieter Hofmann
Oct 11, 2005·Journal of Neuropathology and Experimental Neurology·Rosane B OliveiraEuzenir N Sarno

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