TGFbeta3 expression in non-syndromic orofacial clefts

International Journal of Pediatric Otorhinolaryngology
Rosario RulloF Carinci

Abstract

Genetic studies have demonstrated that non-syndromic cleft is composed of two separate entities - cleft palate only (CPO) and cleft of lip, alveolus with or without cleft palate (CL+/-P) -, both have a heterogeneous genetic background and environmental factors contribute to the onset of these malformations. Previous studies have shown that TGFbeta3 could be involved in these diseases, but no conclusive results have been reached. In order to detect if TGFbeta3 has a role in cleft diseases, a series of non-syndromic cleft patients and controls are analyzed for TGFbeta3 protein expression. Forty-three non-syndromic cleft patients and 21 unaffected subjects were involved in this study. Paraffin-embedded specimens were matched with the TGFbeta3 antibody and then scanned with a computerized image analyzer. TGFbeta3 was found to be absent (less than 10%), moderate (from 10% to 30%) and highly expressed (higher than 30%) in epithelium (EP), minor palatal salivary gland (GL) and fibres of elevator palati muscle (MU). Data was statistically analyzed with a Kruskal-Wallis test. Only GL and EP have a statistically significant lower expression in non-syndromic cleft compared to unaffected subjects. A subsequent comparison between CL+/-P and...Continue Reading

References

Dec 24, 2010·Human Molecular Genetics·Isabella VenzaMario Venza
Sep 9, 2008·Expert Opinion on Biological Therapy·Jinghua HaoDong-An Wang

Citations

Oct 1, 1988·The Pediatric Infectious Disease Journal·J Siegel
Mar 3, 1998·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·G D SinghS Lozanoff
Feb 12, 2000·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·F CarinciM Tognon

Related Concepts

Buffers
Pathogenic Aspects
Tooth Socket
Barrett Esophagus
Pathogenesis
Specimen Type - Fibroblasts
Structure of Papilla Incisiva of Mouth
Glycosaminoglycans
Kruskal-Wallis Test
Murine

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