Th-17 cells infiltrate the liver in human biliary atresia and are related to surgical outcome

Journal of Pediatric Surgery
Richard HillMark Davenport

Abstract

Biliary atresia (BA), a cholangiopathy of unknown etiology is associated with intrahepatic mononuclear cell infiltrate. An abnormal reaction to viral exposure has been hypothesized in some cases. We aimed to investigate the nature of the CD4+ hepatic infiltrate in defined clinical variants of BA by quantification of inflammatory cell components. Liver biopsies of infants obtained at Kasai portoenterostomy (KPE) were stained immunohistochemically using monoclonal antibodies to Tbet, GATA-3, FOXP3 and interleukin (IL) 17, identifying Th-1, Th-2, Tregs and Th-17 cells respectively. T cells were counted with the aid of a graticule. Data are reported as median (range) of cells per high-power-field (×400) and compared using nonparametric statistical tests with P≤0.05 regarded as significant. Liver biopsies from BA (n=37) and age-matched cholestatic controls (e.g. alpha-1-anti trypsin deficiency, Alagilles syndrome, n=12) were investigated. BA infants were divided into three groups: cytomegalovirus IgM +ve (CMV; n=9); BA splenic malformation (BASM; n=9) and isolated BA (IBA; n=19). All T-cell subsets were present in the portal tracts, with an overrepresentation of Th-1 (P<0.001) and Th-17 (P<0.03), but not Th-2 (P=0.94) or Tregs (P=0....Continue Reading

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Citations

Nov 23, 2015·Pediatric Surgery International·Athanasios Tyraskis, Mark Davenport
Jan 23, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Yuhua ShanQiang Xia
Dec 15, 2015·Journal of Pediatric Surgery·Mark Davenport
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Sep 25, 2017·Pediatric Surgery International·Mark Davenport
May 16, 2018·The Cochrane Database of Systematic Reviews·Athanasios TyraskisMark Davenport
Sep 24, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kang LiShao-Tao Tang
Feb 2, 2018·The Pediatric Infectious Disease Journal·Akshat GoelIra Shah
Nov 23, 2018·World Journal of Pediatrics : WJP·Wen-Jun ShenShan Zheng
Oct 25, 2017·Pediatric Surgery International·Alexandra Kilgore, Cara L Mack
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Jan 15, 2019·Journal of Clinical and Translational Hepatology·Leon D Averbukh, George Y Wu
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Mar 5, 2019·F1000Research·Andrew WehrmanRebecca G Wells
May 8, 2019·Hepatology Communications·Sehee KimUNKNOWN Childhood Liver Disease Research Network
Mar 2, 2021·Pediatric Surgery International·Enrico La PergolaMark Davenport

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