TH-A-BRCD-01: Electron Radiotherapy: Past, Present, and Future

Medical Physics
J Antolak, K Hogstrom

Abstract

Delivery constraints on monitor units (MUs) are not currently considered during optimization of intensity modulated proton therapy (IMPT) planning in our treatment planning system (TPS). This may result in differences between the delivered and ideally optimized dose distributions. The purpose of this study is to develop a deliverable optimization algorithm incorporating MU constraints (DOMU) in IMPT treatment planning and evaluate its clinical applicability. A novel objective formula was incorporated with the limited-memory Broyden-Fletcher-Goldfarb-Shannon (L-BFGS) algorithm to directly optimize the deliverable IMPT plan with minimum MU constraint (0.005 MUs per spot). Treatment plans for a homogeneous phantom were generated for different spot spacings, using optimization without MU constraints and post-processing (OMPP) and DOMU. A treatment plan for a head-neck cancer patient prescribed to 63 Gy was also designed with DOMU using different spot spacings. For all plans, the dose-volume-histograms (DVHs) were analyzed to evaluate the benefits of the DOMU. For the regular shaped homogeneous phantom, only the plan generated by OMPP using 5mm spacing showed pronounced dose distortion compared to ideally optimized dose. Plan using ...Continue Reading

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