Th1 cells induce and Th2 inhibit antigen-dependent IL-12 secretion by dendritic cells

European Journal of Immunology
F RiaL Adorini

Abstract

Dendritic cells are the most relevant antigen-presenting cells (APC) for presentation of antigens administered in adjuvant to CD4+ T cells. Upon interaction with antigen-specific T cells, dendritic cells (DC) expressing appropriate peptide-MHC class II complexes secrete IL-12, a cytokine that drives Th1 cell development. To analyze the T cell-mediated regulation of IL-12 secretion by DC, we have examined their capacity to secrete IL-12 in response to stimulation by antigen-specific Th1 and Th2 DO11.10 TCR-transgenic cells. These cells do not differ either in TCR clonotype or CD40 ligand (CD40L) expression. Interaction with antigen-specific Th1, but not Th2 cells, induces IL-12 p40 and p75 secretion by DC. The induction of IL-12 production by Th1 cells does not depend on their IFN-gamma secretion, but requires direct cell-cell contact mediated by peptide/MHC class II-TCR and CD40-CD40L interactions. Th2 cells not only fail to induce IL-12 secretion, but they inhibit its induction by Th1 cells. Unlike stimulation by Th1, inhibition of IL-12 production by Th2 cells is mediated by soluble molecules, as demonstrated by transwell cultures. Among Th2-derived cytokines, IL-10, but not IL-4 inhibit Th1-driven IL-12 secretion. IL-10 prod...Continue Reading

References

May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·U GublerP C Familletti
Jan 1, 1991·Annual Review of Immunology·R M Steinman
Oct 4, 1990·Journal of Immunological Methods·M T CrowleyR M Steinman
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A S SternR Chizzonite
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·L AdoriniE Appella
Dec 1, 1988·The Journal of Experimental Medicine·L AdoriniZ A Nagy
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M PratS Landolfo
Jan 1, 1995·The Journal of Experimental Medicine·J P LeonardS J Goldman
Nov 1, 1995·The Journal of Experimental Medicine·M F NeurathW Strober
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R A SederW E Paul
Jan 28, 1994·Cell·W E Paul, R A Seder
Nov 1, 1993·Immunology Today·W F WadeJ C Cambier
Feb 1, 1993·Immunological Reviews·T Chatila, R S Geha
Jan 1, 1996·The Journal of Experimental Medicine·X MaG Trinchieri
Oct 31, 1996·Nature·A K AbbasA Sher
Jan 20, 1997·The Journal of Experimental Medicine·C WinzlerP Ricciardi-Castagnoli
May 1, 1997·European Journal of Immunology·T De SmedtM Moser
Jul 1, 1997·European Journal of Immunology·J C GuéryL Adorini

❮ Previous
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Citations

Feb 10, 2000·Springer Seminars in Immunopathology·M R ShurinM T Lotze
Feb 6, 2004·Immunology Letters·Anders Elm PedersenMogens Helweg Claesson
Mar 24, 2004·Trends in Immunology·Rémi J Creusot, N Avrion Mitchison
Sep 21, 2000·Immunology Letters·F OssendorpC J Melief
Feb 1, 2000·Immunology Today·B Seddon, D Mason
Feb 19, 2000·Current Opinion in Immunology·S D ReidL Adorini
Feb 15, 2002·British Journal of Haematology·F VuillierD Scott-Algara
Nov 20, 2015·BioMed Research International·Tiffany Caza, Steve Landas
May 15, 2018·International Journal of Molecular Sciences·Yosef EllenbogenManel Jordana
Aug 31, 2018·International Immunology·Masaaki KawanoSho Matsushita
Feb 27, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Constanze KuehnBarbara Dietel
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·F AloisiL Adorini
Aug 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·P KalińskiM L Kapsenberg
Aug 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·H KahlertH Fiebig
Jan 13, 2000·International Journal of Experimental Pathology·M SchuylerK J Nikula
Nov 12, 2014·Infection and Immunity·Katina SchinnerlingThomas Schneider
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G Penna, L Adorini
May 13, 2004·Clinical and Diagnostic Laboratory Immunology·L Aurelian
May 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Romina PenitenteFrancesco Ria
Jul 14, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D von BubnoffT Bieber
Jan 21, 2020·Immunological Reviews·Charlie BridgewoodDennis McGonagle
Sep 21, 2007·Multiple Sclerosis : Clinical and Laboratory Research·S Kern, T Ziemssen
Oct 15, 2005·Journal of Immunotherapy·Judy C PengLars K Nielsen
Nov 3, 2005·Current Opinion in Allergy and Clinical Immunology·Isil B BarlanCezmi A Akdis
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francesco RiaLuciano Adorini
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A G PaulR van der Zee
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S EbnerN Romani
Dec 2, 2004·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·P BoonthamO Eremin

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