Th1 polarization of the immune response in uveitis in Behçet's disease

Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Fulya IlhanAhmet Gödekmerdan

Abstract

It has been reported that abnormalities in the balance of T-helper cells type 1/2 (Th1/Th2) may account for the pathophysiology of human autoimmune diseases. The purpose of this study was to define the role of the Th1/Th2 balance in the pathogenesis of uveitis in Behçet's disease (BD). From February 2003 to August 2005, we studied 31 patients with active BD. Of these patients, 21 (12 female, 9 male; mean age 35.5 [SD 10] years) presented with acute uveitis, and 10 (7 female, 3 male; mean age 34 [SD 11] years) presented with inflammatory arthritis but no prior uveitis attack. The control group consisted of 10 (7 female, 3 male; mean age 34.7 [SD 8] years) age-matched, healthy individuals. CD4+ CD26+ and CD4+ CD30+ cell surface expression of the peripheral blood CD4+ T lymphocytes was evaluated by analytic flow cytometry in order to determine percentages of Th1 and Th2 lymphocyte subsets. The mean percentage of CD4+ CD26+ and CD4+ CD30+ cells was 26.27 (SD 6.18) % and 2.56 (SD 0.82) %, 17.42 (SD 5.90) % and 2.86 (SD 0.72) %, and 14.99 (SD 3.96) % and 3.11 (SD 1.25) % in BD with active uveitis, BD with inflammatory arthritis but no prior uveitis attack, and control groups, respectively. T-helper 1 (Th1) cell percentage was signifi...Continue Reading

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Citations

Apr 23, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Houda BelguendouzChafia Touil-Boukoffa
May 12, 2012·Rheumatology International·Esin Aktas CetinGunnur Deniz
Jun 27, 2009·Cancer Immunology, Immunotherapy : CII·Oscar J CorderoMontserrat Nogueira
Jul 26, 2014·Journal of Immunology Research·Un Chul ParkHyeong Gon Yu
Jan 30, 2014·Autoimmunity Reviews·Cloé ComarmondDavid Saadoun
Jul 6, 2013·Acta Microbiologica Et Immunologica Hungarica·Elaheh VanakiZohreh Jadali
Sep 20, 2016·International Journal of Speech-language Pathology·Maria LennoxDavid Trembath
Sep 18, 2021·Frontiers in Immunology·S M Shamsul IslamSeonghyang Sohn

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