Th1-polarizing immunization with egg antigens correlates with severe exacerbation of immunopathology and death in schistosome infection

Proceedings of the National Academy of Sciences of the United States of America
Laura I RutitzkyMiguel J Stadecker

Abstract

In schistosomiasis mansoni, parasite eggs precipitate an intrahepatic granulomatous and fibrosing inflammatory process, which is mediated by, and dependent on, MHC class II-restricted CD4 T helper (Th) lymphocytes specific for schistosome egg antigens (SEA). In the mouse model of the disease, CBA mice develop large granulomas, whereas in C57BL/6 (BL/6) mice these granulomas are significantly smaller. To further investigate how the prevailing cytokine environment influences the development of the egg-induced immunopathology, we immunized the low-pathology BL/6 mice with SEA in complete Freund's adjuvant (CFA) once before, and once again during, the course of a 7-week infection. This immunization caused a pronounced Th1 shift in the SEA-specific CD4 T cell response, which was detected in the mesenteric lymph nodes (MLNs) and spleens, as well as in the granulomatous lesions themselves. The immunized mice displayed a dramatic enhancement of hepatic egg-induced immunopathology manifested by a marked increase in granuloma size and parenchymal inflammation, leading to early death. Control mice immunized with equivalent amounts of SEA or CFA alone displayed the smaller hepatic lesions in a Th2-dominant environment typically seen in the...Continue Reading

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Citations

Oct 26, 2012·Seminars in Immunopathology·Bridget M LarkinMiguel J Stadecker
May 15, 2003·Acta Tropica·Edward J Pearce
May 10, 2003·Trends in Immunology·William C GauseMiguel J Stadecker
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Nov 22, 2011·PLoS Neglected Tropical Diseases·Xiaoyun WenChuan Su
Oct 15, 2011·PLoS Pathogens·Patrick M SmithMiguel J Stadecker
Jun 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Nicolas PrevostLawrence F Brass
Sep 14, 2004·Immunological Reviews·Miguel J StadeckerJing Sun
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Aug 29, 2009·European Journal of Immunology·Laura I RutitzkyMiguel J Stadecker
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Jan 18, 2020·BioMed Research International·Martina SombetzkiEmil C Reisinger
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew J EdwardsPersephone Borrow
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura I RutitzkyMiguel J Stadecker
Oct 18, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mara G ShainheitMiguel J Stadecker
May 29, 2020·Protoplasma·Miriam BischofsbergerMartina Sombetzki
Dec 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Colleen M KaneEdward J Pearce
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura I RutitzkyMiguel J Stadecker

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