Th1/17 Polarization of CD4 T Cells Supports HIV-1 Persistence during Antiretroviral Therapy

Journal of Virology
Hong SunMathias Lichterfeld

Abstract

The ability to persist long term in latently infected CD4 T cells represents a characteristic feature of HIV-1 infection and the predominant barrier to efforts aiming at viral eradication and cure. Yet, increasing evidence suggests that only small subsets of CD4 T cells with specific developmental and maturational profiles are able to effectively support HIV-1 long-term persistence. Here, we analyzed how the functional polarization of CD4 T cells shapes and structures the reservoirs of HIV-1-infected cells. We found that CD4 T cells enriched for a Th1/17 polarization had elevated susceptibilities to HIV-1 infection in ex vivo assays, harbored high levels of HIV-1 DNA in persons treated with antiretroviral therapy, and made a disproportionately increased contribution to the viral reservoir relative to their contribution to the CD4 T memory cell pool. Moreover, HIV-1 DNA levels in Th1/17 cells remained stable over many years of antiretroviral therapy, resulting in a progressively increasing contribution of these cells to the viral reservoir, and phylogenetic studies suggested preferential long-term persistence of identical viral sequences during prolonged antiretroviral treatment in this cell compartment. Together, these data sug...Continue Reading

References

Jun 25, 1993·Nucleic Acids Research·Z Yang, J D Engel
May 10, 2007·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Nov 21, 2007·Seminars in Immunology·Brigitta StockingerBruno Martin
Aug 30, 2008·Blood·Jinfang Zhu, William E Paul
Jan 3, 2009·Immunity·Yun Kyung LeeCasey T Weaver
Feb 4, 2009·The Journal of Clinical Investigation·David BendingAnne Cooke
Jun 16, 2009·Nature Medicine·Luca GattinoniNicholas P Restifo
Jun 23, 2009·Nature Medicine·Nicolas ChomontRafick-Pierre Sékaly
Oct 17, 2009·Nature Reviews. Microbiology·Mayte CoirasJosé Alcamí
Jan 1, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Annie GosselinPetronela Ancuta
Feb 11, 2010·The Journal of Infectious Diseases·Aimee El HedDerya Unutmaz
Mar 3, 2010·Annual Review of Immunology·Jinfang ZhuWilliam E Paul
Mar 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patricia MonteiroPetronela Ancuta
Sep 20, 2011·Nature Medicine·Luca GattinoniNicholas P Restifo
Oct 15, 2011·Science Translational Medicine·Ilona KryczekWeiping Zou
Dec 20, 2011·Immunity·Pawel MuranskiNicholas P Restifo
Sep 25, 2012·Immunity·Evelyn Eisele, Robert F Siliciano
Dec 21, 2012·The Journal of Experimental Medicine·Matthieu PerreauGiuseppe Pantaleo
Jan 3, 2013·The Journal of Clinical Investigation·Enrico LugliMario Roederer
Jan 18, 2013·Blood·Pawel Muranski, Nicholas P Restifo
Apr 2, 2013·Lancet·Christine KatlamaRafick P Sekaly
May 18, 2013·Nature Reviews. Immunology·Stuart G TangyeElissa K Deenick
Dec 18, 2013·Nature Reviews. Immunology·Donna L FarberNicholas P Restifo
Jan 15, 2014·Nature Medicine·Maria J BuzonMathias Lichterfeld
Feb 6, 2014·PLoS Pathogens·Kristin L BoswellRichard A Koup
Apr 15, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emily K CartwrightGuido Silvestri
Jan 31, 2015·Cell·Lillian B CohnMichel C Nussenzweig
Feb 24, 2015·Frontiers in Immunology·J Scott Hale, Rafi Ahmed

❮ Previous
Next ❯

Citations

Feb 16, 2016·Trends in Microbiology·Kirston BartonSarah Palmer
May 24, 2016·EBioMedicine·Clovis S PalmerSuzanne M Crowe
Jul 16, 2016·PLoS Pathogens·Rémi FromentinNicolas Chomont
Mar 16, 2016·Scientific Reports·Mohamed El-FarUNKNOWN Investigators of the Canadian HIV+ Slow Progressor Cohort
Jun 20, 2017·The Journal of Clinical Investigation·Kyungyoon J Kwon, Robert F Siliciano
Feb 23, 2018·Frontiers in Immunology·Daniela TeixeiraIeda Maria Longo-Maugéri
Sep 9, 2017·AIDS Research and Human Retroviruses·Shahzada KhanShomyseh Sanjabi
May 31, 2018·Current Opinion in HIV and AIDS·Timothée Bruel, Olivier Schwartz
Dec 14, 2018·Current Opinion in HIV and AIDS·Delphine PlanasPetronela Ancuta
Mar 30, 2016·Current Opinion in HIV and AIDS·Guinevere Q Lee, Mathias Lichterfeld
Aug 5, 2017·JCI Insight·Delphine PlanasPetronela Ancuta
Jan 11, 2020·Frontiers in Microbiology·Shane D FalcinelliNancie M Archin
May 28, 2020·Frontiers in Cellular and Infection Microbiology·Shokichi Takahama, Takuya Yamamoto
Jun 26, 2020·Frontiers in Cellular and Infection Microbiology·Kubra F Naqvi, Janice J Endsley
Apr 23, 2020·Frontiers in Cellular and Infection Microbiology·Jordan ThomasGeorgios Pollakis
Sep 30, 2020·ELife·Jason NeidlemanNadia R Roan
Oct 26, 2018·Retrovirology·Elizabeth M Anderson, Frank Maldarelli
Jan 11, 2020·Nature Communications·Hany Zekaria MeåsTrude Helen Flo
May 3, 2020·Biology of Sex Differences·Letizia SantinelliGabriella d'Ettorre
Oct 17, 2019·Frontiers in Immunology·Gilles DarcisAlexander O Pasternak
Nov 8, 2018·Cells·Pilar Garcia-BroncanoUNKNOWN GESIDA 3603b Study Group
Aug 23, 2019·Current Immunology Reviews·Ronald S Veazey
Sep 18, 2020·Chinese Medical Journal·Jia-Cong Zhao, Kai Deng
Dec 5, 2020·Chinese Medical Journal·Jia-Cong Zhao, Kai Deng
Mar 26, 2021·Clinical Pharmacology and Therapeutics·Courtney V FletcherSiddappa N Byrareddy

❮ Previous
Next ❯

Related Concepts

Related Feeds