Th17 cells in autoimmune disease: changing the verdict

Immunotherapy
Stefan HaakBurkhard Becher

Abstract

Th17 cells and their proinflammatory signature cytokine, IL-17, have recently replaced Th1 cells to be the essential Th effector population in autoimmune disease. This was based on a similar line of evidence that previously destined Th1 cells to be the sole encephalitogenic Th-cell effector type. However, as for the Th1-effector type before, an increasing amount of evidence is accumulating that questions the pivotal role of Th17 cells in autoimmunity. Recently, four high-impact articles were published that clearly show that Th1 and Th17 cells carry encephalitogenic properties, and dominance of either in an autoimmune setting can confer disease. In two mouse models for autoimmune neuroinflammation, it was suggested that Th1 and Th17 cells act in parallel, both exhibiting a different set of effector mechanisms.

References

Aug 22, 2002·The Journal of Clinical Investigation·Burkhard BecherRandolph J Noelle
Jan 20, 2005·The Journal of Experimental Medicine·Claire L LangrishDaniel J Cua
Jan 18, 2006·The Journal of Clinical Investigation·Jingsong WangLaurie H Glimcher
May 4, 2006·The Journal of Clinical Investigation·Yi ChenDaniel J Cua
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yutaka KomiyamaYoichiro Iwakura
Nov 1, 2006·Critical Reviews in Immunology·Yoshiro Kobayashi
Dec 5, 2006·Trends in Immunology·Ingo BechmannV Hugh Perry
May 4, 2007·The Journal of Clinical Investigation·Ilona Gutcher, Burkhard Becher
Sep 4, 2007·Current Opinion in Immunology·Estelle BettelliVijay K Kuchroo
Feb 19, 2008·Nature Medicine·Ingunn M StromnesJoan M Goverman
Mar 19, 2008·The Journal of Experimental Medicine·Thaddeus CarlsonBenjamin Segal
Apr 11, 2008·Immunity·Mandy J McGeachy, Daniel J Cua
Jul 2, 2008·The Journal of Experimental Medicine·Lawrence Steinman
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Richard A O'ConnorStephen M Anderton
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jimmy W LeeDaniel S Straus

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Citations

Sep 27, 2013·PloS One·Jianqin HeLanjuan Li
Dec 12, 2012·International Journal for Parasitology·Elsenoor J KlaverIrma van Die
Feb 10, 2012·Immunopharmacology and Immunotoxicology·Farhad Jadidi-Niaragh, Abbas Mirshafiey
Sep 25, 2016·Autoimmunity Reviews·Gagandeep KaurShifali Singla
Nov 23, 2011·Toxicologic Pathology·Brad Bolon
Jan 20, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katharine E BlockHaochu Huang

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Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

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