Th17 cytokines and arthritis.

Seminars in Immunopathology
Erik Lubberts

Abstract

Th17 cells are implicated in human autoimmune diseases, such as rheumatoid arthritis (RA), although it has not been established whether this persistent destructive arthritis is driven by Th1 and/or Th17 cells. Interleukin-17A (IL-17A) contributes to the pathogenesis of arthritis as has been shown in several experimental arthritis models. Importantly, recent data from first clinical trials with anti-IL-17A antibody treatment in psoriatic arthritis patients and RA patients looks promising. This review summarizes the findings about the role of Th17 cells in arthritis and discusses the impact of the different Th17 cytokines in the pathogenesis of this disease. However, further studies are needed to unravel the interplay between IL-17A and other Th17 cytokines such as IL-17F, IL-22, and IL-21 in the pathoimmunological process of this crippling disease, in particular, whether regulating Th17 cell activity or specific combinations of Th17 cytokines will have additional value compared to neutralizing IL-17A activity alone. Moreover, tumor necrosis factor-positive Th17 cells are discussed as potential dangerous cells in driving persistent arthritis in human early RA.

References

Jul 15, 1999·Scandinavian Journal of Immunology·T AarvakJ B Natvig
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M ZiolkowskaW Maslinski
Nov 18, 2000·Arthritis and Rheumatism·K KurasawaI Iwamoto
Nov 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C Infante-DuarteT Kamradt
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·E LubbertsW B van den Berg
Feb 13, 2002·Arthritis and Rheumatism·Henk VisserJohanna M W Hazes
May 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Susumu NakaeYoichiro Iwakura
May 16, 2003·Nature·Gary S Firestein
Sep 17, 2003·Nature Reviews. Immunology·Jean-Christophe Renauld
Dec 10, 2003·The Journal of Experimental Medicine·Craig A MurphyDaniel J Cua
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ismé M de KleerBerent Prakken
Dec 4, 2004·The Journal of Clinical Investigation·Reiko HoraiYoichiro Iwakura
Jan 12, 2005·Arthritis Research & Therapy·Erik LubbertsWim B van den Berg
Apr 9, 2005·Arthritis and Rheumatism·Hidekazu IkeuchiYoshihisa Nojima
Jun 9, 2005·The Journal of Experimental Medicine·Claudia R RuprechtFederica Sallusto
Jul 30, 2005·International Immunology·Duncheng WangLee Ann Garrett-Sinha
Aug 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erik LubbertsJay K Kolls
Sep 20, 2006·The Journal of Experimental Medicine·Spencer C LiangLynette A Fouser
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Deborah HerberKyri Dunussi-Joannopoulos
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lili XuWarren Strober
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hee-Kap KangSyamal K Datta
Aug 28, 2007·Annals of the Rheumatic Diseases·A H SawalhaJ B Harley
Oct 31, 2007·The Journal of Experimental Medicine·Jacques MoisanI-Cheng Ho

❮ Previous
Next ❯

Citations

Oct 19, 2010·Cellular and Molecular Life Sciences : CMLS·Merouane BencherifMario B Marrero
Aug 29, 2013·Seminars in Immunopathology·Nam Trung NguyenTadamitsu Kishimoto
Oct 5, 2011·Clinical Rheumatology·Feng-Lai YuanJun-Ming Sun
Oct 26, 1995·Journal of Immunological Methods·A R Mire-SluisR Thorpe
Dec 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Gordon S DuncanTak W Mak
Mar 7, 2013·Stem Cells and Development·Yunsheng LiSonglin Wang
Aug 29, 2013·International Journal of Rheumatic Diseases·Gholamreza AziziAbbas Mirshafiey
Aug 3, 2012·Clinical and Vaccine Immunology : CVI·Brian T CampfieldAndrew J Nowalk
May 6, 2011·Arthritis Research & Therapy·Thomas Kamradt, Hyun-Dong Chang
Oct 27, 2011·PloS One·Christian D SadikAndrew D Luster
Nov 5, 2013·Clinical & Developmental Immunology·Min WangDaoxin Ma
Jun 24, 2014·Journal of Immunology Research·Claes HanssonGerd-Marie Alenius
Feb 11, 2014·Immunology Letters·K Kerry KoP Mark Hogarth
Jan 15, 2014·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Michelly Cristiny PereiraMaira Galdino Da Rocha Pitta
Dec 8, 2010·Journal of Clinical Immunology·Joana HyginoCleonice Alves de Melo Bento
Nov 24, 2011·Clinical & Developmental Immunology·Yan ShiHuaxi Xu
Jan 19, 2013·Annals of the Rheumatic Diseases·Jan Piet van HamburgErik Lubberts
Feb 7, 2012·Inflammation and Regeneration·Fumiaki KojimaLeslie J Crofford
Dec 22, 2012·Expert Opinion on Therapeutic Targets·Tian TianDaoxin Ma
Oct 1, 2014·The Journal of Investigative Dermatology·Mayuko YamamotoShigetoshi Sano
Aug 29, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Hua YuKamal D Moudgil
Feb 22, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ahmed M Abu El-AsrarJo Van Damme
Jan 5, 2011·Molecular Immunology·Xuemei Zhong, Thomas L Rothstein
Jun 2, 2010·Biochemical and Biophysical Research Communications·Xia LiRui-sheng Xu
Dec 15, 2015·Nature Reviews. Rheumatology·Iain B McInnesJohn D Isaacs
Jun 29, 2012·European Journal of Immunology·Yoon-Sook LeeChang-Yuil Kang
Sep 6, 2012·European Journal of Immunology·Aurélie AmbrosiMarie Wahren-Herlenius
Jan 21, 2012·Scandinavian Journal of Immunology·Y Bi, R Yang
Apr 17, 2014·Journal of Clinical Periodontology·Wan-Chien ChengLeonie S Taams

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
FACS

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.