Th1/Th17/Th22 immune response and their association with joint pain, imagenological bone loss, RANKL expression and osteoclast activity in temporomandibular joint osteoarthritis: A preliminary report

Journal of Oral Rehabilitation
G MonasterioRolando Vernal

Abstract

It is well accepted that the presence of cytokines belonging to the Th1/Th17/Th22 axis of immuno-inflammatory response in the joint environment, such as IL-1β, IL-17 and IL-22, respectively, are associated with pathogenesis of several synovial joint degenerative disorders. During temporomandibular joint osteoarthritis (TMJ-OA), IL-1β and IL-17 have been implicated in the inflammation and resorption of sub-chondral bone; however, the role of Th22 response in the TMJ-OA pathophysiology has not been established. This study aimed to compare the expression of Th1/Th17/Th22-type cytokines, chemokines and chemokine receptors in synovial fluid samples obtained from TMJ-OA or disk displacement with reduction (DDWR) patients. In addition, it aimed to associate these levels with joint pain, imagenological signs of bone degeneration, RANKL production, osteoclastogenesis and osteoclast-induced bone resorption. Higher levels of IL-1β, IL-17 and IL-22 were expressed in TMJ-OA compared with DDWR subjects, and these increased levels significantly correlated with RANKL expression, joint pain and articular bone degeneration. Higher levels of CCR5, CCR6 and CCR7, as well as their respective ligands CCL5 and CCL20, responsible for recruitment of IL...Continue Reading

References

Jan 5, 2001·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A TanakaN Matsumoto
Jul 17, 2001·Cells, Tissues, Organs·M A KacenaM C Horowitz
Feb 28, 2002·Annual Review of Immunology·Lars E TheillJosef M Penninger
May 16, 2003·Nature·William J BoyleDavid L Lacey
May 4, 2004·The British Journal of Oral & Maxillofacial Surgery·Keiseki KaneyamaHiroshi Yoshimura
Nov 8, 2006·The Journal of Experimental Medicine·Kojiro SatoHiroshi Takayanagi
Sep 6, 2007·Journal of Cellular Physiology·Mary B Goldring, Steven R Goldring
May 30, 2008·Archives of Oral Biology·Rolando VernalMariano Sanz
Dec 17, 2008·Infectious Disorders Drug Targets·Rolando Vernal, Jose A Garcia-Sanz
Apr 8, 2011·Journal of Dental Research·M HernándezJ Gamonal
May 11, 2011·Journal of Clinical Immunology·Lei ZhangGuang-Hui Wang
Mar 20, 2012·Journal of Dental Research·X D WangY H Zhou
Feb 15, 2013·Immunological Reviews·Mark H Kaplan
Jul 3, 2013·Dental Clinics of North America·Frederick Liu, Andrew Steinkeler
Feb 1, 2014·Journal of Oral & Facial Pain and Headache·Eric SchiffmanUNKNOWN Orofacial Pain Special Interest Group, International Association for the Study of Pain
Apr 29, 2015·The Journal of Headache and Pain·Larissa Soares Reis VilanovaPer Alstergren
Oct 18, 2015·International Journal of Oral and Maxillofacial Surgery·I M DiasR de S Tesch
Feb 3, 2018·Journal of Oral Rehabilitation·P AlstergrenS Kopp

❮ Previous
Next ❯

Citations

Aug 2, 2019·Journal of Immunoassay & Immunochemistry·Camila Medeiros CostaAndrei Pereira Pernambuco
Mar 20, 2020·Mediators of Inflammation·Yoke Yue Chow, Kok-Yong Chin
Oct 13, 2020·Journal of Oral Rehabilitation·Nicolás Patricio SkármetaGary M Heir
Nov 23, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Candelaria LeiguardaPablo R Brumovsky

❮ Previous
Next ❯

Related Concepts

Related Feeds