PMID: 8585759Sep 1, 1995Paper

Th1/Th2-like immunity and resistance to herpes simplex labialis

Antiviral Research
S L SpruanceA S Abramovitz

Abstract

To investigate potential immunologic mechanisms of resistance to recurrent herpes simplex labialis, we assayed serum antibody titers and cultured peripheral blood mononuclear cell (PBMC) cytokine production among patients with a history of frequent episodes (H+S+), herpes simplex virus (HSV)-seropositive individuals without a history of herpes labialis (H-S+) and HSV-seronegative persons (H-S-). In addition, H+S+ patients were exposed to experimental ultraviolet radiation (UVR) on the lips and the immunologic assay results compared among those who developed experimental lesions and those who did not. H+S+ patients were found to have higher median serum titers of HSV antibody and trends to lower levels of HSV-specific PBMC IFN-gamma and IL-2 than H-S+ control patients (123 vs 66, P = 0.04; 424 vs 548 pg/ml, P = 0.08; 14 vs 26 pg/ml, P = 0.14, respectively). Correlation of the results with the occurrence of experimental lesions showed the inverse: the subgroup of H+S+ patients with UVR-induced lesions had lower titers of antibody and trends to higher levels of IFN-gamma and IL-2 than H+S+ patients who could not be induced (93 vs 149, P = 0.02; 501 vs 347 pg/ml, P = NS; 26 vs 11 pg/ml, P = NS, respectively). The size and duration ...Continue Reading

References

Oct 1, 1992·Journal of Immunotherapy·R A Daynes, B A Araneo
Aug 29, 1991·The New England Journal of Medicine·S CohenA P Smith
Nov 22, 1990·The New England Journal of Medicine·UNKNOWN National Institutes of Health-University of California Expert Panel for Corticosteroids as Adjunctive Therapy for Pneumocyst
Oct 1, 1987·The Journal of General Virology·M NorvalJ P Maingay
Nov 1, 1988·The Journal of Experimental Medicine·K Hayakawa, R R Hardy
Dec 1, 1988·Immunology Today·C E Rudd
Sep 1, 1988·Immunology Today·K Bottomly
Sep 1, 1985·The Journal of Infectious Diseases·S Kohl
Jan 1, 1985·Antiviral Research·B Meignier, B Roizman
May 1, 1986·The Journal of Infectious Diseases·J W Torseth, T C Merigan
Mar 18, 1972·British Medical Journal·J M WiltonT Lehner
Sep 1, 1984·Diagnostic Microbiology and Infectious Disease·V C SalmonJ C Overall
Aug 6, 1981·The New England Journal of Medicine·W C ReevesK K Holmes
Jun 1, 1983·Ophthalmology·H E KaufmanE D Varnell
Jul 8, 1994·Science·T R Mosmann
Oct 8, 1993·Science·J Cohen

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Citations

Jul 25, 2003·Human Immunology·Rekha SinghFrancisco Diaz-Mitoma
Mar 18, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L R StanberryC J Lacey
Jan 18, 2008·The Journal of Infectious Diseases·Maurine R HobbsJohn D Kriesel
Nov 11, 2003·Clinical and Diagnostic Laboratory Immunology·B JiangR I Glass
Jan 15, 2003·Clinical Microbiology Reviews·David M Koelle, Lawrence Corey
Jun 14, 2012·Herpesviridae·Paul R KinchingtonRobert L Hendricks
Oct 18, 2007·Journal of the American Academy of Dermatology·Mahnaz Fatahzadeh, Robert A Schwartz
Jan 27, 2007·Photodermatology, Photoimmunology & Photomedicine·Robert M SayreMingyi W Trimble
Feb 12, 1998·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·G W RabornW T McGaw
Dec 10, 2013·Arthritis Research & Therapy·Maria I RamosMaria C Lebre
Apr 6, 2002·The Journal of the American Dental Association·G Wayne RabornUNKNOWN Worldwide Topical Penciclovir Collaborative Study Group
Jan 16, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·C HullS Spruance
Jan 17, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Paolo G Arduino, Stephen R Porter
Oct 27, 2011·Journal of Medical Virology·Francesca Pica, Antonio Volpi

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