TH2 and 'TH2-like' cells in allergy and asthma: pharmacological perspectives

Trends in Pharmacological Sciences
G P Anderson, A J Coyle

Abstract

Recently, considerable progress has been made in understanding the molecular basis by which cytokines released from CD4+ helper T cells contribute to allergic disease. A subset of CD4+ helper T cells, termed TH2 cells, produce interleukin 4 (IL-4) and IL-5, but not interferon gamma. IL-4 has a critical role in causing B-cell immunoglobulin-isotype switch leading to IgE synthesis, and IL-5 governs eosinophilic inflammation of airway tissue. Studies on the mechanisms whereby TH2 cells, and non-T cells such as metachromatic cells, produce a highly restricted panel of cytokines has revealed molecular mechanisms that may affect our views on the induction and treatment of asthma, and these are discussed in this review by Gary Anderson and Anthony Coyle. TH2 cytokine biology may enable pharmacologists to design better, and perhaps even preventative, therapies for the treatment of asthma and allergy. Surprisingly IL-4, rather than IL-5, is emerging as a critical drug target owing to its central role in the regulation of CD4+ helper T cell phenotype commitment.

References

Oct 1, 1992·The Journal of Clinical Investigation·A E PostlethwaiteR Raghow
Nov 1, 1992·The Journal of Experimental Medicine·P BraddingC H Heusser
Jan 30, 1992·The New England Journal of Medicine·D S RobinsonA B Kay
Jan 1, 1992·British Journal of Pharmacology·T IwamaA Koda
May 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P G GibsonF E Hargreave
Mar 1, 1991·The Journal of Clinical Investigation·C Y WuG Delespesse
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S Z Ben-SassonW E Paul
Jul 1, 1988·European Journal of Immunology·S Bergstedt-LindqvistE Severinson
Jun 1, 1970·The Journal of Experimental Medicine·A Basten, P B Beeson
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J PunnonenJ E de Vries
Mar 1, 1993·The American Review of Respiratory Disease·A J Van OosterhoutF P Nijkamp

❮ Previous
Next ❯

Citations

Jul 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·I PaegelowU Wartner
Feb 1, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Shuhan YanXuming Deng
Jul 20, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Michał ZimeckiMarian L Kruzel
Apr 1, 1996·Journal of Pharmacological and Toxicological Methods·A HatzelmannC Schudt
May 18, 2005·Comparative Immunology, Microbiology and Infectious Diseases·D Y LoW C Lee
Apr 2, 2003·Toxicology and Applied Pharmacology·Tong-Rong JanNorbert E Kaminski
Jan 1, 1997·Pharmacology & Therapeutics·S P Hogan, P S Foster
Sep 13, 2002·Journal of Neuroimmunology·Halina OffnerChristopher L Reading
Feb 13, 2001·Trends in Pharmacological Sciences·C Walker, C Zuany-Amorim
Feb 1, 1995·Trends in Pharmacological Sciences·A J Van Oosterhout, H F Savelkoul
Sep 18, 1997·Immunology Today·T Wilckens, R De Rijk
Feb 15, 2001·Clinics in Dermatology·G L Capella, A F Finzi
Jan 1, 1997·Research in Immunology·J A Lasky, A R Brody
Jun 1, 1996·Current Opinion in Immunology·L L Carter, R W Dutton
Sep 12, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·N J KenyonN N Jarjour
Oct 3, 2002·Nature Reviews. Drug Discovery·Claudia Zuany-AmorimChristoph Walker
May 30, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Guha KrishnaswamyDavid S Chi
Mar 8, 2005·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Elisabete Regis CarneiroVera Lucia Flor Silveira
Nov 28, 2013·Current Opinion in Pulmonary Medicine·Nathan Hambly, Parameswaran Nair
Nov 2, 2012·Current Opinion in Pulmonary Medicine·Ting-Yu LinQutayba Hamid
Sep 9, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Christophe MariatXin Xiao Zheng
Dec 31, 1997·American Journal of Respiratory and Critical Care Medicine·E A KellyN N Jarjour
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·H E FlemingH A Boushey
Apr 14, 2000·American Journal of Respiratory and Critical Care Medicine·P G KnottC P Bertrand
Mar 11, 2000·American Journal of Respiratory and Critical Care Medicine·G P Anderson
Jun 1, 1996·American Journal of Respiratory and Critical Care Medicine·J A Denburg
Mar 22, 2005·American Journal of Respiratory Cell and Molecular Biology·Johan ForssellJonas S Erjefält
May 6, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Martin Hersberger
Mar 2, 2010·Future Medicinal Chemistry·Prakash NagarkattiMitzi Nagarkatti
Apr 15, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M LampinenP Venge
May 3, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R J MayerL A Marshall
Jun 26, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A TrifilieffC Bertrand
Mar 5, 2015·Molecular Medicine Reports·Wenbo Zhou, Xiuhong Nie
Aug 24, 2010·International Immunopharmacology·Mee-Young LeeHyeun-Kyoo Shin
Nov 21, 2007·European Journal of Pharmacology·Alexandre P RogerioLúcia H Faccioli
Nov 4, 2015·Frontiers in Immunology·Jens GeginatSergio Abrignani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.