Thai generic-brand dry canine foods: mutagenicity and the effects of feeding in vivo and in vitro

BMC Veterinary Research
Tanyalak KhuntamoonKarunee Kwanbunjan

Abstract

The commercial pet-food industry and the market value of the pet industry have increased. Most owners are concerned about their pets' health, and prefer commercial pet foods as their regular diet. This study thus aimed to determine whether a selection of local generic-brand dry canine foods had any potential to promote chronic disease. Five local, generic-brand, dry canine foods were studied for potential mutagenicity; the effects of long-term consumption were also observed in rats. All canine foods were extracted with distilled water and absolute ethanol. The Ames test was used to detect short-term genetic damage, using Salmonella typhimurium tester strains TA98 and TA100. Simultaneously, the long-term effects were studied in an animal model by observing rats fed with these canine foods, compared with normal rat food, for a period of 15 weeks. Using the water extracts, all dry canine foods studied showed considerable mutagenic effects on the tester strains. One brand affected both tester strains, whereas 3 showed positive to TA98, and one to TA100. With the absolute ethanol extract, three of the five brands had a considerable mutagenic effect on TA98, and another affected TA100. In the long-term test, all rats remained alive u...Continue Reading

References

Apr 1, 1991·American Journal of Epidemiology·E G SonnenscheinL J McKee
May 1, 1983·Mutation Research·D M Maron, B N Ames
Dec 30, 1998·The Journal of Nutrition·R F Butterwick, A J Hawthorne
Dec 11, 1999·Mutation Research·B S Strauss
Dec 13, 2000·Mutation Research·K Mortelmans, E Zeiger
Sep 2, 2003·Mutation Research·Mark G KnizeJames S Felton
Oct 15, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·G A Bray
Jul 20, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ali DuranMustafa Soylak

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BETA
dissecting
light microscopy

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Liasys Analyzer Medical System ( AMS
SPSS

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