Thalamic but Not Subthalamic Neuromodulation Simplifies Word Use in Spontaneous Language.

Frontiers in Human Neuroscience
Hannes Ole TiedtFabian Klostermann

Abstract

Several investigations have shown language impairments following electrode implantation surgery for Deep Brain Stimulation (DBS) in movement disorders. The impact of the actual stimulation, however, differs between DBS targets with further deterioration in formal language tests induced by thalamic DBS in contrast to subtle improvement observed in subthalamic DBS. Here, we studied speech samples from interviews with participants treated with DBS of the thalamic ventral intermediate nucleus (VIM) for essential tremor (ET), or the subthalamic nucleus (STN) for Parkinson's disease (PD), and healthy volunteers (each n = 13). We analyzed word frequency and the use of open and closed class words. Active DBS increased word frequency in case of VIM, but not STN stimulation. Further, relative to controls, both DBS groups produced fewer open class words. Whereas VIM DBS further decreased the proportion of open class words, it was increased by STN DBS. Thus, VIM DBS favors the use of relatively common words in spontaneous language, compatible with the idea of lexical simplification under thalamic stimulation. The absence or even partial reversal of these effects in patients receiving STN DBS is of interest with respect to biolinguistic con...Continue Reading

References

Nov 1, 1965·The Quarterly Journal of Experimental Psychology·R C Oldfield, A Wingfield
Oct 1, 1995·Neuropsychologia·L Nickels, D Howard
Feb 1, 1997·Neuropsychologia·A M RaymerL J Rothi
Jul 1, 1997·Brain and Language·S E Nadeau, B Crosson
Oct 24, 1997·Psychological Review·G S DellD A Gagnon
Jan 6, 2000·Journal of the Neurological Sciences·D KarussisO Abramsky
Jan 25, 2000·Journal of the International Neuropsychological Society : JINS·S L Thompson-SchillD A Fleischman
Apr 17, 2001·The Behavioral and Brain Sciences·W J LeveltA S Meyer
Sep 12, 2001·Neurology·W J LombardiR E Gross
Aug 6, 2002·Brain and Language·Fernando CuetosAndrew W Ellis
Nov 9, 2002·Journal of Clinical and Experimental Neuropsychology·Maria Caterina SilveriMaria Puopolo
Feb 18, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·J A FieldsR Pahwa
Mar 29, 2003·Brain and Language·Marcia Radanovic, Milberto Scaff
Jun 5, 2003·Parkinsonism & Related Disorders·Steven Paul WoodsAlexander I Tröster
Aug 23, 2003·Stroke; a Journal of Cerebral Circulation·Jeremy D Schmahmann
Apr 22, 2004·Neuropsychology·Kevin SailorAlan Kluger
May 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·A FunkiewiezP Pollak
Aug 26, 2004·Journal of the International Neuropsychological Society : JINS·Julie D Henry, John R Crawford
Jun 29, 2005·Annals of Neurology·Adam M KossJay L Shils
Jun 28, 2006·Neurology·Emmanuel Carrera, Julien Bogousslavsky
Sep 2, 2006·The Quarterly Journal of Experimental Psychology : QJEP·Eduardo NavarreteAlbert Costa
Aug 16, 2008·Cognitive Neuropsychology·Audrey K KittredgeMyrna F Schwartz
Apr 14, 2009·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Sonja A KotzMaren Schmidt-Kassow
Jul 15, 2009·Trends in Cognitive Sciences·Josef Parvizi
Sep 22, 2009·Journal of the Neurological Sciences·Michele K YorkJoseph Jankovic
Aug 4, 2010·Human Brain Mapping·Zheng YeThomas F Münte
Mar 1, 2004·Cognitive Neuropsychology·Myrna F SchwartzMarcia Polansky
Nov 12, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Claire L TomlinsonCarl E Clarke

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Citations

Nov 25, 2021·Current Neurology and Neuroscience Reports·Marcia Radanovic, Victor N Almeida

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