Thalamic Circuit Diversity: Modulation of the Driver/Modulator Framework

Frontiers in Neural Circuits
Martha E Bickford

Abstract

The idea that dorsal thalamic inputs can be divided into "drivers", which provide the primary excitatory drive for the relay of information to cortex, and "modulators", which alter the gain of signal transmission, has provided a valuable organizing principle for the study of thalamic function. This view further promoted the identification of "first order" and "higher order" thalamic nuclei, based on the origin of their driving inputs. Since the introduction of this influential terminology, a number of studies have revealed the existence of a wide variety of thalamic organizational schemes. For example, some thalamic nuclei are not innervated by typical driver inputs, but instead receive input from terminals which exhibit features distinct from those of either classic drivers or modulators. In addition, many thalamic nuclei contain unique combinations of convergent first order, higher order, and/or other "driver-like" inputs that do not conform with the driver/modulator framework. The assortment of synaptic arrangements identified in the thalamus are reviewed and discussed from the perspective that this organizational diversity can dramatically increase the computational capabilities of the thalamus, reflecting its essential rol...Continue Reading

References

Dec 2, 1977·Brain Research·M P Ogren, A E Hendrickson
Jun 1, 1976·Journal of Neurocytology·D A Winfield, T P Powell
Sep 1, 1975·The Journal of Comparative Neurology·C D Gilbert, J P Kelly
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D A McCormick, M von Krosigk
Dec 15, 1990·The Journal of Comparative Neurology·D Raczkowski, D Fitzpatrick
May 8, 1987·The Journal of Comparative Neurology·J E HamosS M Sherman
Sep 1, 1966·The Journal of Comparative Neurology·R W Guillery
Jun 9, 1971·Nature: New Biology·B G ClelandW R Levick
Sep 1, 1972·The Journal of Comparative Neurology·L H Mathers
Mar 11, 1969·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·E G Jones, T P Powell
Sep 1, 1972·The Journal of Comparative Neurology·L H Mathers
Jan 1, 1968·Experimental Brain Research·K Majorossy, M Réthelyi
Jan 1, 1969·Zeitschrift für Zellforschung und mikroskopische Anatomie·R W Guillery
Jun 1, 1969·Brain Research·H J Ralston, M M Herman
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·A ErişirS M Sherman
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·S M Sherman, R W Guillery
Jun 9, 2000·Annual Review of Neuroscience·S H Hendry, R C Reid
Aug 15, 2001·The Journal of Comparative Neurology·R W GuilleryD P Van Lieshout
Sep 29, 2001·Trends in Neurosciences·E G Jones
Oct 18, 2002·The European Journal of Neuroscience·P BarthóL Acsády
Mar 11, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·S Murray Sherman, R W Guillery
Aug 2, 2003·Journal of Neurophysiology·Jianli LiMartha E Bickford
Aug 6, 2003·The Journal of Comparative Neurology·Larry R KellyMartha E Bickford
Jan 1, 1963·Acta Anatomica·J SZENTAGOTHAI
May 14, 2004·Journal of Neurophysiology·Iva Reichova, S Murray Sherman
Mar 17, 2005·The Journal of Comparative Neurology·Marc Nahmani, Alev Erisir
Mar 19, 2005·The Journal of Comparative Neurology·Zsolt B BaldaufMartha E Bickford
Mar 19, 2005·The Journal of Comparative Neurology·Zsolt B BaldaufMartha E Bickford
Mar 31, 2005·Neuron·Hajnalka BokorLászló Acsády
May 26, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anders KiellandPaul Heggelund
Mar 5, 2008·The Journal of Comparative Neurology·Martha E BickfordAygul B Dankowsi
Mar 21, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Agnes L BodorLászló Acsády
Jul 11, 2008·The Journal of Comparative Neurology·Ranida D ChomsungMartha E Bickford
Sep 23, 2008·Current Opinion in Neurobiology·Farran Briggs, W Martin Usrey
Sep 26, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander GrohThomas Kuner

❮ Previous
Next ❯

Citations

Jul 22, 2017·NeuroImage·Kathleen S Rockland
Mar 16, 2018·The European Journal of Neuroscience·Kathleen S Rockland
Mar 15, 2016·The Journal of Comparative Neurology·Jonathan D Day-BrownMartha E Bickford
May 23, 2019·Neural Computation·Nima Dehghani, Ralf D Wimmer
Mar 27, 2018·The European Journal of Neuroscience·Martha E Bickford
Nov 21, 2019·Journal of Neurophysiology·Lukas SchneiderMelanie Wilke
Dec 19, 2017·Reviews in the Neurosciences·Ismael ConejeroEmilie Olié
Jun 20, 2020·Annual Review of Vision Science·Farran Briggs
Nov 6, 2018·Chemical Senses·Kelly E FredericksenChad L Samuelsen
Nov 9, 2018·Frontiers in Systems Neuroscience·John W Crabtree
Jan 1, 2017·Visual Neuroscience·J Michael Hasse, Farran Briggs
Oct 3, 2017·Visual Neuroscience·N A ZhouMartha E Bickford
Feb 20, 2021·Frontiers in Neural Circuits·Kathleen S Rockland
Sep 1, 2020·Neuroscience·Akira Arafune-MishimaNoritaka Ichinohe
Jul 21, 2021·Proceedings of the National Academy of Sciences of the United States of America·Vandana SampathkumarNarayanan Kasthuri
Oct 7, 2021·Current Biology : CB·Megan A KirchgessnerEdward M Callaway
Oct 16, 2021·Neuroscience of Consciousness·Tomáš MarvanWilliam A Phillips

❮ Previous
Next ❯

Methods Mentioned

BETA
electron microscopy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.