Thalamic-projecting preprocholecystokinin messenger RNA-expressing neurons in the dorsal column nuclei of the rat

Neuroscience
S FarneboA Blomqvist

Abstract

This study aimed at investigating the expression of preprocholecystokinin messenger RNA among thalamic-projecting neurons in the dorsal column nuclei of the rat. Thalamic-projecting neurons were identified by injection of cholera toxin subunit b into the ventroposterolateral nucleus. Following immunohistochemical detection of retrogradely transported tracer substance, the expression of preprocholecystokinin messenger RNA in the projection neurons of the dorsal column nuclei was detected by in situ hybridization, using autoradiographic visualization of a 35S-labeled RNA probe complementary to preprocholecystokinin messenger RNA. Many preprocholecystokinin-expressing neurons were seen in the dorsal column nuclei. A large proportion of these neurons were also labeled with cholera toxin. The double-labeled neurons, as well as neurons single-labeled with preprocholecystokinin messenger RNA or cholera toxin, were preferentially found within the middle region of the dorsal column nuclei, located just caudal to the obex. These findings demonstrate that neurons in the dorsal column nuclei express preprocholecystokinin messenger RNA, and show that these neurons provide a peptidergic projection from the dorsal column nuclei to the ventrop...Continue Reading

References

May 11, 1992·Neuroscience Letters·S MaslanyM D Egger
Jul 1, 1991·Brain Research. Molecular Brain Research·L Abelson, P E Micevych
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M SchallingM Goldstein
Feb 1, 1990·Brain Research. Molecular Brain Research·K B SeroogyE R Perl
Jan 1, 1985·Journal of Neurochemistry·J F Rehfeld
Sep 1, 1986·Brain Research·K J BerkleyM Bull
Jan 8, 1987·The Journal of Comparative Neurology·L A Mantle-St John, D J Tracey
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R J DeschenesJ E Dixon
Jun 1, 1993·Progress in Neurobiology·N LindeforsH Persson

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