Thalamocortical Axonal Activity in Motor Cortex Exhibits Layer-Specific Dynamics during Motor Learning

Neuron
Yasuyo H TanakaMasanori Matsuzaki

Abstract

The thalamus is the hub through which neural signals are transmitted from the basal ganglia and cerebellum to the neocortex. However, thalamocortical axonal activity during motor learning remains largely undescribed. We conducted two-photon calcium imaging of thalamocortical axonal activity in the motor cortex of mice learning a self-initiated lever-pull task. Layer 1 (L1) axons came to exhibit activity at lever-pull initiation and termination, while layer 3 (L3) axons did so at lever-pull initiation. L1 population activity had a sequence structure related to both lever-pull duration and reproducibility. Stimulation of the substantia nigra pars reticulata activated more L1 than L3 axons, whereas deep cerebellar nuclei (DCN) stimulation did the opposite. Lesions to either the dorsal striatum or the DCN impaired motor learning and disrupted temporal dynamics in both layers. Thus, layer-specific thalamocortical signals evolve with the progression of learning, which requires both the basal ganglia and cerebellar activities.

Citations

Apr 19, 2020·Annual Review of Neuroscience·Junchol ParkJoshua T Dudman
Apr 23, 2020·Frontiers in Neuroinformatics·Hiroshi YamauraTadashi Yamazaki
Mar 4, 2019·The Cerebellum·Christophe HabasPierre Cabaraux
Jul 24, 2020·Scientific Reports·Peilin ZhaoXiangning Li
Dec 29, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Hilary ToulminA David Edwards
Oct 27, 2020·Frontiers in Behavioral Neuroscience·Sai TanimotoMasanori Matsuzaki
Nov 14, 2020·Nature Reviews. Neuroscience·Mary T Joy, S Thomas Carmichael
Jul 19, 2019·Neuron·Alex J Yonk, David J Margolis
Nov 14, 2020·Current Opinion in Neurobiology·Ioana Genescu, Sonia Garel
Oct 22, 2019·Neuroscience Research·Yoshikazu Ugawa
Jun 14, 2021·Journal of Neuroscience Methods·Gerard Joey Broussard, Leopoldo Petreanu
Jul 25, 2021·Current Biology : CB·Naoya TakahashiDieter Jaeger
Mar 18, 2021·Annual Review of Neuroscience·Benjamin SchumanBernardo Rudy
Aug 19, 2021·Journal of Neural Engineering·S BowlesC G Welle

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