Thalamocortical connectivity is enhanced following functional hemispherotomy for intractable lateralized epilepsy

Epilepsy & Behavior : E&B
George M IbrahimO Carter Snead

Abstract

Although developmental outcomes may improve following functional hemispherotomy for lateralized, catastrophic childhood epilepsy, the neuronal processes mediating these improvements are unknown. We report the case of a 14-year-old child with neurocognitive impairment who underwent functional hemispherotomy with longitudinal resting-state fMRI. Compared with preoperative fMRI, we report significantly more robust thalamo-default mode network connectivity on postoperative neuroimaging. Furthermore, we show decreased connectivity to nodes within the disconnected hemisphere, providing direct evidence that functional interactions are dependent upon structural connectivity. Since the vascular supply to these nodes remains intact, although they are disconnected from the remainder of the brain, these findings also confirm that blood-oxygen level dependent oscillations are driven primarily by neuronal activity. The current study highlights the importance of thalamocortical interactions in the understanding of neural oscillations and cognitive function, and their impairment in childhood epilepsy.

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Citations

Mar 24, 2016·Journal of X-ray Science and Technology·Zhen TanGuoming Luan
Jul 26, 2016·Frontiers in Human Neuroscience·Ammar H HawasliEric C Leuthardt
Nov 4, 2017·Journal of Neurosurgery. Pediatrics·Anthony C WangJeffrey G Ojemann
Jan 24, 2018·Journal of Neurophysiology·George M IbrahimAndres A Lozano
Mar 23, 2018·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Alessandra MolettoPiernanda Vigliano
Apr 11, 2019·Journal of Neurophysiology·Daniel J MartireGeorge M Ibrahim
Oct 23, 2020·Neurology·Andrea S Nahum, Frédérique J Liégeois
Dec 15, 2019·Trends in Neurosciences·Tim BayneMarcello Massimini
Sep 23, 2021·Journal of Neurophysiology·Olivia N ArskiGeorge M Ibrahim

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