Thalamus Controls Development and Expression of Arousal States in Visual Cortex

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Yasunobu Murata, Matthew T Colonnese

Abstract

Two major checkpoints of development in cerebral cortex are the acquisition of continuous spontaneous activity and the modulation of this activity by behavioral state. Despite the critical importance of these functions, the circuit mechanisms of their development remain unknown. Here we use the rodent visual system as a model to test the hypothesis that the locus of circuit change responsible for the developmental acquisition of continuity and state dependence measured in sensory cortex is relay thalamus, rather than the local cortical circuitry or the interconnectivity of the two structures. We conducted simultaneous recordings in the dorsal lateral geniculate nucleus (dLGN) and primary visual cortex (VC) of awake, head-fixed male and female rats using linear multielectrode arrays throughout early development. We find that activity in dLGN becomes continuous and positively correlated with movement (a measure of state dependence) on P13, the same day as VC, and that these properties are not dependent on VC activity. By contrast, silencing dLGN after P13 causes activity in VC to become discontinuous and movement to suppress, rather than augment, cortical firing, effectively reversing development. Thalamic bursting, a core charac...Continue Reading

Citations

Oct 28, 2019·Sleep·María Corsi-CabreraThalia Harmony
Oct 31, 2019·Current Sleep Medicine Reports·James C DooleyMark S Blumberg
Jul 24, 2020·Scientific Reports·Peilin ZhaoXiangning Li
Jun 26, 2020·Science Advances·Yasunobu Murata, Matthew T Colonnese
Jan 15, 2021·American Journal of Physical Medicine & Rehabilitation·Yoo Jin ChooMin Cheol Chang
Oct 17, 2020·Cerebral Cortex·Zihao ZhangJoost X Maier
May 25, 2021·Frontiers in Neuroinformatics·Ruben A Tikidji-Hamburyan, Matthew T Colonnese
Aug 31, 2020·Current Opinion in Physiology·Mark S BlumbergGreta Sokoloff
Jul 23, 2021·Neuron·Francisco J MartiniGuillermina López-Bendito

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