Thalamus volume and ambulation in multiple sclerosis: a cross-sectional study

Neurodegenerative Disease Management
Robert W MotlRalph H B Benedict

Abstract

This cross-sectional study examined if subcortical gray matter (SGM) structures accounted for differences in timed 25-foot walk (T25FW) speed between multiple sclerosis (MS) patients and controls. Subjects underwent brain MRI and completed the T25FW. Volumes of the thalamus, caudate, putamen and pallidum were calculated from 3D T1-weighted structural brain images. T2 lesion volume (T2LV) was determined by using a semiautomated edge detection contouring-thresholding technique. There were differences in T25FW speed, SGM volumes and T2LV between MS and controls. T25FW speed was associated with SGM volumes and T2LV in MS and controls. Thalamic volume partially accounted for the difference in T25FW speed between the MS and controls. The reduction of thalamus volume is associated with compromised ambulation in MS patients.

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Citations

Jun 12, 2016·Journal of the Neurological Sciences·Bardia NourbakhshEmmanuelle Waubant
Oct 11, 2016·NeuroImage. Clinical·Leah H SuttnerRussell T Shinohara
Jan 12, 2017·Neurodegenerative Disease Management·Rachel E KlarenRobert W Motl
Oct 5, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Daniel Ontaneda, Robert J Fox
Feb 20, 2018·Journal of Neurosciences in Rural Practice·Halil Onder
May 26, 2018·Expert Review of Neurotherapeutics·Nicolas CollonguesTobias Derfuss
Oct 23, 2019·Neural Regeneration Research·Maria Marcella LaganaFrancesca Baglio
May 10, 2020·AJNR. American Journal of Neuroradiology·I KalininE Evdoshenko
Apr 21, 2021·Multiple Sclerosis and Related Disorders·Ghaith J AndrowisJohn DeLuca
May 1, 2021·International Journal of Environmental Research and Public Health·Jessica F Baird, Robert W Motl

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Software Mentioned

Integrated Registration and Segmentation Tool
FMRIB
SIENAX
SPSS Statistics

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