PMID: 6106748Sep 13, 1980Paper

Thalassaemia as a model of recessive genetic disease in the community

Lancet
M MouzourasR Gale

Abstract

In order to gain understanding of some of the problems of genetic counseling for a severe recessive disease in England, a Greek Cypriot extended family including 87 living members and known to be transmitting a beta-thalassaemia gene was investigated for the extent and the sources of their knowledge about thalassaemia. 42% of members tested carried beta-thalassaemia trait: nearly half were already aware of this, but only 10% of the non-carriers were aware of their status. The study illustrated many of the difficulties in conveying accurate counselling to a whole community and the need for active involvement of all health workers, especially general practitioners. This study is also relevant to the approaching possibility of genetic counseling for cystic fibrosis.

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Citations

Dec 1, 1995·Prenatal Diagnosis·M Petrou, B Modell
Nov 29, 1980·Lancet
Oct 29, 2004·Nature Reviews. Genetics·Nadeem QureshiMichael Modell
Oct 11, 2002·The New England Journal of Medicine·Suhaib AhmedMary Petrou
Jul 1, 1989·Journal of Reproductive and Infant Psychology·M P M Richards
May 1, 1991·Journal of Medical Genetics·E CobbJ A Raeburn
Feb 15, 2012·Asia-Pacific Journal of Public Health·Yupin JopangFrank Peter Schelp
Jan 1, 1984·Medical Informatics = Médecine Et Informatique·A Rossi-MoriG Zambon

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