Thalassemia and hemoglobinopathies in an ethnic minority group in Central Vietnam: implications to health burden and relationship between two ethnic minority groups

Journal of Community Genetics
Nga Thi NguyenS Fucharoen

Abstract

Thalassemia is a genetic condition that can result in long and expensive treatments, and severe thalassemia may lead to death if left untreated. Couples contributing two genes for thalassemia place their children at particular risk for severe thalassemia. Gene frequency of thalassemia varies in Vietnam, but presents remarkably high levels among some ethnic minority groups. Limited information about thalassemia frequency makes prevention and control of thalassemia difficult. This study aimed to determine gene frequency of certain types of thalassemia among 390 women of reproductive age of the Ta-Oi ethnic minority. Hemoglobin and DNA analyses were carried out to diagnose thalassemia and hemoglobinopathies. Of the total participants, 56.1% (95% CI = 51.1-61.1) carried thalassemia genes. A remarkably high frequency of hemoglobin Constant Spring (Hb CS) of 23.8% (95% CI = 19.7-28.4) was noted. The frequency of α(+)-thalassemia (-3.7 kb deletion) was 26.4% (95% CI = 22.1-31.1), while hemoglobin E (Hb E) and hemoglobin Paksé (Hb Ps) were identified at frequencies of 14.6 (95% CI = 11.2-18.5) and 2.6% (95% CI = 1.4-5.0), respectively. Further analysis of α-globin gene haplotype revealed the same Hb CS haplotype (+ - M + + -) as of the...Continue Reading

References

Feb 22, 2005·Annals of Tropical Paediatrics·Vip ViprakasitVoravarn S Tanphaichitr
Mar 28, 2006·Annals of Hematology·Goonnapa FucharoenSupan Fucharoen
May 24, 2008·Public Health Nutrition·Erin McLeanBruno de Benoist
May 26, 2010·British Journal of Haematology·Sean O'RiordanDavid Weatherall
Jan 25, 2012·Bulletin of the World Health Organization·Ahmad Reza HosseinpoorTies Boerma
Sep 7, 2012·Cold Spring Harbor Perspectives in Medicine·Thomas N Williams, David J Weatherall
Apr 23, 2013·Hemoglobin·Hoa Van NguyenFrank P Schelp
Oct 8, 2015·Acta Haematologica·Kasama WongprachumFrank P Schelp

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