Thalassemia and hemoglobinopathies in pregnant Lao women: carrier screening, prevalence and molecular basis

Annals of Hematology
Onekham SavongsyNattaya Sae-Ung


To provide relevant evidence base for implementation of a prevention and control program for thalassemia in the Lao People's Democratic Republic (Lao PDR), we have evaluated a simple screening protocol and examined the prevalence and the molecular basis of thalassemia in pregnant Lao women. The study was conducted on 307 pregnant women attending the Mother and Child Health Hospital, Vientiane. Initial screening was performed locally, applying a combined osmotic fragility (OF) and dichlorophenolindophenol (DCIP) test. Erythrocyte counts were recorded. The remaining blood specimens were transferred to Thailand for further hemoglobin (Hb) and DNA analyses. Subjects were divided into four groups according to the results of the screening tests. Among 307 participants examined, 154 (50.2%) had negative results on both tests (-/-), 58 (18.8%) were positive on the OF test but not the DCIP test (+/-), 22 (7.1%) were negative on the OF test but positive on the DCIP test (-/+), and 73 (23.7%) were positive on both tests (+/+). As many as 25 thalassemia genotypes including various complex syndromes were observed. Three clinically important forms of thalassemia including alpha(o)-, beta-thalassemia, and Hb E were identified in 39 (12.7%), 1...Continue Reading


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Related Concepts

Hemoglobin E
Heterozygote Detection
Osmotic Fragility Test
Antenatal Screening Procedures
Sodium 2,6-Dichloroindophenol
Beta Thalassemia
Genetic Carriers
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