PMID: 8443047Jan 1, 1993Paper

Thalassemia: lung function with reference to iron studies and reactive oxidant status

Pediatric Hematology and Oncology
D K LuytS G Reinach

Abstract

Pulmonary function tests were performed in 15 thalassemic patients (age 5 years 8 months to 18 years 6 months), receiving both regular transfusions and desferrioxamine, to determine the presence and nature of any abnormalities in lung function. Reactive oxidant production from neutrophils was measured simultaneously to ascertain if a causal relationship existed between free radical production and tissue damage in the lungs. Mean total lung capacity, mean residual volume, and mean forced vital capacity were significantly reduced, indicating a restrictive pattern of lung function abnormality. In addition, the carbon monoxide diffusion was low, and hypoxemia was present in 6 of 13 patients tested. These pulmonary function abnormalities did not correlate with age, cumulative volume of transfusion, or serum ferritin levels. In addition, neutrophil reactive oxidant status did not correlate with these or with pulmonary function parameters. These results indicate that neutrophil-derived oxygen free radicals do not appear to be a major cause of lung function abnormalities in thalassemics.

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Citations

May 8, 2001·Indian Journal of Pediatrics·M AroraA K Dutta
Mar 16, 2007·Journal of Pediatric Hematology/oncology·Ankit ParakhHarmanjeet Singh Hira
Sep 24, 2002·Archives of Disease in Childhood·A M LiT F Fok
Jul 1, 2006·Acta Haematologica·G PiattiM D Cappellini
Feb 14, 2012·Pediatric Pulmonology·Evangelia BourliVictor Aivazis
Feb 25, 2017·Journal of Pediatric Hematology/oncology·Savas Dedeoglu, Helen Bornaun
May 9, 2006·American Journal of Hematology·Denise H Tam, Harrison W Farber
Aug 30, 2008·Pediatric Hematology and Oncology·Azita AzarkeivanParvaneh Vosough
Jan 5, 2002·Blood·Amiram Eldor, Eliezer A Rachmilewitz
Apr 22, 2017·Case Reports in Neurological Medicine·Behnaz AnsariAli Asghar Okhovat
Aug 16, 2017·Indian Journal of Clinical Biochemistry : IJCB·Ashwini KumarVivek Ambade

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