Thalidomide effect in endothelial cell of acute radiation proctitis.

World Journal of Gastroenterology : WJG
Ki-Tae KimSuk-Jin Kang

Abstract

To determine whether thalidomide prevents microvascular injury in acute radiation proctitis in white rats. Fourteen female Wistar rats were used: six in the radiation group, six in the thalidomide group, and two in normal controls. The radiation and thalidomide groups were irradiated at the pelvic area using a single 30 Gy exposure. The thalidomide (150 mg/kg) was injected into the peritoneum for 7 d from the day of irradiation. All animals were sacrificed and the rectums were removed on day 8 after irradiation. The microvessels of resected specimens were immunohistochemically stained with thrombomodulin (TM), von Willebrand Factor (vWF), and vascular endothelial growth factor (VEGF). The microscopic scores did not differ significantly between the radiation and thalidomide groups, but both were higher than in the control group. Expression of TM was significantly lower in the endothelial cells (EC) of the radiation group than in the control and thalidomide groups (P<0.001). The number of capillaries expressing vWF in the EC was higher in the radiation group (15.3+/-6.8) than in the control group (3.7+/-1.7), and the number of capillaries expressing vWF was attenuated by thalidomide (10.8+/-3.5, P<0.001). The intensity of VEGF ex...Continue Reading

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Citations

Dec 23, 2011·Radiation Oncology·Maximilian NiyaziClaus Belka
Jan 25, 2013·World Journal of Gastroenterology : WJG·Abobakr K ShadadLaurence J Egan
Mar 16, 2013·Current Opinion in Supportive and Palliative Care·Rhodri Stacey, John T Green
Aug 19, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yanlan ChaiZi Liu
Mar 27, 2013·International Journal of Radiation Biology·Saske HovingFiona A Stewart
Mar 29, 2018·Frontline Gastroenterology·Michael McFarlaneBenjamin R Disney
Jun 15, 2018·Journal of Radiation Research·Sei Hwan YouChang Geol Lee
Mar 14, 2020·International Journal of Molecular Sciences·Hyosun JangSehwan Shim

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