PMID: 11905508Mar 22, 2002Paper

Thalidomide in cancer

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
S Singhal, J Mehta

Abstract

Thalidomide has immunomodulatory and anti-angiogenic properties which may underlie its activity in cancer. After its success in myeloma, it has been investigated in other plasma cell dyscrasias, myelodysplastic syndromes, gliomas, Kaposi's sarcoma, renal cell carcinoma, advanced breast cancer, and colon cancer. Thalidomide causes responses in 30-50% of myeloma patients as a single agent, and acts synergistically with corticosteroids and chemotherapy. Thalidomide results in the reduction or elimination of transfusion-dependence in some patients with myelodysplastic syndrome. Responses have also been seen in one-third of patients with Kaposi's sarcoma, in a small proportion of patients with renal cell carcinoma and high-grade glioma, and in some patients with colon cancer in combination with irinotecan. The drug is being investigated currently in a number of clinical trials for cancer. Drowsiness, constipation, and fatigue are common side effects, whereas peripheral neuropathy and skin rash are seen in one-third. A minority of patients experience bradycardia. Thrombotic phenomena are especially common when thalidomide is combined with chemotherapy. Adverse effects severe enough to necessitate cessation of therapy are seen in arou...Continue Reading

References

Mar 1, 1991·The Journal of Experimental Medicine·E P SampaioG Kaplan
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·R J D'AmatoJ Folkman
Jul 1, 1994·British Journal of Haematology·A VaccaF Dammacco
Oct 1, 1993·Fogorvosi szemle·M OroszD Schuller
Jun 1, 1993·The Journal of Experimental Medicine·A L MoreiraG Kaplan
Jan 1, 1995·European Journal of Clinical Pharmacology·C C HarlandJ R Marsden
Sep 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R A SolèrD Nadal
Jun 12, 1998·International Archives of Allergy and Immunology·S Partida-SanchezI Estrada-Garcia
Jan 1, 1997·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·A L MoreiraG Kaplan
Jan 5, 1999·International Journal of STD & AIDS·K FifeM Bower
Oct 8, 1999·Pharmacotherapy·S B Horowitz, A L Stirling
Nov 24, 1999·The New England Journal of Medicine·S SinghalB Barlogie
Feb 26, 2000·British Journal of Haematology·A KnellerI Ben-Bassat
Apr 1, 2000·The New England Journal of Medicine·Y KishiU Machida
Apr 27, 2000·The New England Journal of Medicine·A Tefferi
Jun 10, 2000·International Journal of Dermatology·M WalchnerG Messer
Jun 17, 2000·American Journal of Clinical Oncology·Y Z PattK A Waugh
Jul 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S M BaidasD F Hayes
Aug 19, 2000·Lancet·R GovindarajanM Hauer-Jensen
Sep 30, 2000·The New England Journal of Medicine·S V RajkumarT E Witzig
Jun 23, 2001·The New England Journal of Medicine·K OsmanS V Rajkumar
Jul 27, 2001·British Journal of Haematology·G BarosiM Marchetti
Aug 1, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A SantoroC Carnaghi

❮ Previous
Next ❯

Citations

Dec 5, 2002·International Journal of Hematology·Steve MillerPaulette Mehta
May 7, 2003·International Journal of Hematology·Seema Singhal, Jayesh Mehta
Sep 2, 2005·Cancer Chemotherapy and Pharmacology·Christian ZimmermannJuergen Drewe
Apr 30, 2003·Current Treatment Options in Oncology·Seema Singhal, Jayesh Mehta
Dec 31, 2003·Bioorganic & Medicinal Chemistry Letters·Sandrine PérinoBernard Pucci
Aug 11, 2004·Fertility and Sterility·Sejal P DhariaCynthia Cater
Mar 22, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·G Mathé
Dec 4, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Linda E Bröker, Giuseppe Giaccone
Mar 12, 2004·Critical Reviews in Oncology/hematology·Alessandro MorabitoGiampietro Gasparini
Dec 14, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Rudolf KirchmairDouglas W Losordo
Nov 20, 2002·British Journal of Haematology·J R González-PorrasJ F San Miguel
Oct 6, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Maya GuglinAnne B Curtis
Nov 1, 2002·Current Opinion in Oncology·Noopur Raje, Kenneth C Anderson
Jul 14, 2007·International Journal of Clinical Practice·C-C ChiouC-H Yang
Apr 17, 2003·Postgraduate Medical Journal·J N Gordon, P M Goggin
Jul 16, 2010·Dermatology Research and Practice·R RiaA Vacca
Feb 17, 2005·Oncology·Ranjan C V MascarenhasDavid H Van Thiel
Jul 22, 2008·Magyar onkologia·György Blaskó
Apr 6, 2004·Leukemia & Lymphoma·Richard BairdSaad M B Rassam
Jul 2, 2003·Expert Opinion on Investigational Drugs·Massimo FanelliGiampietro Gasparini
Jul 15, 2015·Case Reports in Gastrointestinal Medicine·Matthew P SoapeEverardo Cobos
Nov 6, 2008·Journal of Experimental & Clinical Cancer Research : CR·Shiwu ZhangBaocun Sun
Aug 2, 2003·Organic Letters·Scott M CapitostiMilton L Brown
Aug 19, 2003·The Annals of Pharmacotherapy·Maria R NascaDennis P West
Jul 5, 2003·The Annals of Pharmacotherapy·Amandeep KaurTeresa B Chiao
Aug 16, 2005·The Journal of Investigative Dermatology·Elisabeth Heere-RessBurkhard Jansen
Sep 17, 2008·Journal of Surgical Oncology·Liviu MosoiaJacques Baulieux
Dec 17, 2009·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Nobuhiro OobaKiyoshi Kubota
Jul 20, 2005·Journal of Surgical Oncology·Jurstine DaruwallaChris Christophi
Feb 4, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Amanda C Peltier, James W Russell
Mar 7, 2006·Japanese Journal of Clinical Oncology·Wei-Chung HsuGau-De Lin
Sep 29, 2011·Nihon Hansenbyō Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association·Norihisa IshiiRie Roselyne Yotsu
Jun 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tim Eisen
Apr 21, 2018·Biomedicines·Barbara KaltschmidtChristian Kaltschmidt
Aug 7, 2015·Toxics·Gabriella NicoliniArianna Scuteri
Apr 3, 2004·The Medical Journal of Australia·John Coutsouvelis, Carmela E Corallo
Nov 16, 2019·European Journal of Pharmacology·Michał AntoszczakAdam Huczyński

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.