Thalidomide induces clinical remission and mucosal healing in adults with active Crohn's disease: a prospective open-label study

Therapeutic Advances in Gastroenterology
Yao HeMin-Hu Chen

Abstract

Thalidomide is effective in inducing and maintaining clinical remission in children and adolescents with refractory Crohn's disease (CD). However, little is known about the efficacy and safety of thalidomide for adult patients with CD. We conducted a prospective open-label cohort study between January 2013 and April 2015. A total of 47 adult patients with active CD who were dependent/resistant or intolerant to corticosteroids and/or immunomodulators or biologics received 50-100 mg of thalidomide daily. Primary outcome was clinical remission evaluated at week 8. Endoscopic assessment was performed at week 24 and defined as endoscopic response (decrease in Crohn's Disease Endoscopic Index of Severity [CDEIS] score > 5 points from baseline CDEIS of 6 or more), complete endoscopic remission (CDEIS score < 3), and mucosal healing (MH) (no ulceration). A total of 47 adults with active CD were enrolled. The clinical remission rate was 14.9% and 23.4% at week 4 and week 8, but increased to 46.8% at week 12 and 53.2% at week 24 out of all the 47 patients included (intention-to-treat analysis). Altogether 32 patients consented and underwent ileocolonoscopy at week 24. The rate of endoscopic response and complete endoscopic remission were...Continue Reading

References

Apr 23, 2002·Journal of Gastroenterology and Hepatology·Carolyn BariolAndrew Field
Aug 13, 2002·Journal of Clinical Gastroenterology·Sunanda KaneEli Ehrenpreis
Mar 5, 2004·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·N B Hershfield
Feb 20, 2007·Alimentary Pharmacology & Therapeutics·S PlamondonM A Kamm
Jun 20, 2007·Annals of Internal Medicine·Peter Mannon
Apr 16, 2010·The New England Journal of Medicine·Jean Frédéric ColombelUNKNOWN SONIC Study Group
Dec 17, 2011·World Journal of Gastroenterology : WJG·Márcio Rios LeiteGenoile Oliveira Santana
Oct 24, 2012·Journal of Gastroenterology·Fumiaki UenoUNKNOWN Guidelines Project Group of the Research Group of Intractable Inflammatory Bowel Disease subsidized by the Ministry of Healt
Sep 28, 2013·Journal of Translational Medicine·Jianghong WuShudong Xiao
Nov 28, 2013·JAMA : the Journal of the American Medical Association·Marzia LazzeriniAlessandro Ventura
Sep 14, 2014·Gut·Siew C NgUNKNOWN Asia-Pacific Crohn's and Colitis Epidemiology Study ACCESS Group
Dec 17, 2014·Alimentary Pharmacology & Therapeutics·M E GerichE A Vasiliauskas
Mar 4, 2015·Nature Reviews. Gastroenterology & Hepatology·Ashwin N Ananthakrishnan
Sep 20, 2015·Gastroenterology·Siew C NgUNKNOWN Asia-Pacific Crohn’s and Colitis Epidemiology Study (ACCESS) Group
Nov 26, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·M SimonJ M Gornet
Dec 17, 2015·JAMA : the Journal of the American Medical Association·Christopher J HawkeyDominique Farge

❮ Previous
Next ❯

Citations

Mar 6, 2019·The Journal of International Medical Research·Menghui LiuRen Mao
Jul 8, 2018·Journal of Gastroenterology·Hai Yun Shi, Siew Chien Ng
Apr 28, 2021·Journal of Digestive Diseases·UNKNOWN Inflammatory Bowel Disease Group, Chinese Society of Gastroenterology, Chinese Medical Association

❮ Previous
Next ❯

Methods Mentioned

BETA
contraception
ESR

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
Celeste B Burness, Gillian M Keating
Inflammatory Bowel Diseases
Guillaume BouguenLaurent Peyrin-Biroulet
© 2022 Meta ULC. All rights reserved