Thalidomide inhibited the synthesis of IgM and IgG whereas Thalidomide+Dexamethasone and Dexamethasone alone acted as co-stimulants with pokeweed and enhanced their synthesis

International Immunopharmacology
E J Shannon, F Sandoval

Abstract

Thalidomide (Thal) provides effective treatment for erythema nodosum leprosum (ENL). In combination with Dexamethasome (Dex) it is an effective treatment for multiple myeloma (MM) and Waldenström's macroglobulinemia (WM). Thal's mechanism(s) of action in the treatment of these diverse medical conditions is not known, but it could be suppression of immunoglobulin (Ig) synthesis. Mononuclear cells were stimulated with pokeweed (PWM), and treated with Thal, Thal+Dex or Dex. The cultures were assayed for IgM and IgG. The maximum synthesis was expected to occur in cultures stimulated with PWM at 0.5, 5.0 or 10 microg/ml. The test agents at 15 microM each were expected to alter the response. Compared to cultures stimulated with PWM alone, there was significantly less Ig in the cultures containing Thal+PWM, and significantly more Ig in the cultures containing Thal+Dex+PWM or Dex+PWM (Wilcoxon). The median % of maximum was 57 for cultures treated with Thal+PWM; 184 for cultures treated with Thal+Dex+PWM, and 139 for cultures treated with Dex+PWM. Thal also acted as a co-stimulant with PWM and enhanced the synthesis of IL-2, IL-6 and DNA; whereas, Thal+Dex or Dex enhanced Ig synthesis, but suppressed IL-2, IL-6 and cell proliferation. T...Continue Reading

References

Jan 1, 1988·Fundamental & Clinical Pharmacology·J DescotesJ C Evreux
Aug 24, 1972·The New England Journal of Medicine·H N Claman
Apr 1, 1968·American Journal of Obstetrics and Gynecology·J P Gusdon, C Cohen
Jan 1, 1981·Scandinavian Journal of Immunology·E J ShannonR C Hastings
Nov 24, 1999·The New England Journal of Medicine·S SinghalB Barlogie
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Donna WeberRaymond Alexanian
Jan 12, 2005·Clinical and Diagnostic Laboratory Immunology·A Tadesse, E J Shannon
Aug 21, 2008·Blood·Steven P TreonKenneth C Anderson

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Citations

Mar 3, 2012·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Chris L PashosZeba M Khan
Mar 4, 2014·Nihon Hansenbyō Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association·Masamichi GotoUNKNOWN Japanese Leprosy Association

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