PMID: 9434859Jan 22, 1998Paper

Thalidomide: lack of mutagenic activity across phyla and genetic endpoints

Mutation Research
J AshbyJ Williamson

Abstract

The human and rabbit teratogen thalidomide has been tested for mutagenicity in a wide range of assays, ranging from bacterial gene mutation assays conducted in vitro to in vivo cytogenetic assays conducted using rabbits, and including a variety of human-derived tissues. Thalidomide was not mutagenic to 6 strains of Salmonella when tested both in the presence and absence of Aroclor-induced rat liver S9 mix. This inactivity was confirmed in strains TA98 and TA100 using a 1-h pre-incubation assay protocol with the same S9 mix (10% S9), and additionally, in strain TA98 using 3 concentrations of S9 (4%, 10% and 30% S9 in S9 mix). Thalidomide was not clastogenic either to cultured human lymphocytes (whole blood cultures, minus S9 mix) or to Chinese hamster ovary (CHO) cells treated in vitro. Further, no cytotoxicity was observed in purified human lymphocytes when exposed to thalidomide up to the limit of its solubility in the medium in the presence and absence of liver S9 from Aroclor-induced pregnant rabbit. The CHO assays were conducted without metabolic activation and in the presence of a variety of sources of auxiliary metabolic activation (PB/beta NP-induced rat liver S9 mix, pooled male and female human liver S9 mix, uninduced ...Continue Reading

References

Feb 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I Kimber, D A Basketter
Jan 1, 1987·Mutation Research·J Ashby
Oct 1, 1972·Toxicology and Applied Pharmacology·S S EpsteinY Bishop
Aug 1, 1971·Teratology·C RouxJ L Taillemite
Jun 1, 1966·Die Naturwissenschaften·A T Natarajan, R Nilsson
May 1, 1983·Mutation Research·D M Maron, B N Ames
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G B GordonV Balasubramanian
Jun 8, 1995·Nature·J Ashby, H Tinwell
Aug 1, 1994·Carcinogenesis·H Tinwell, J Ashby
Aug 13, 1994·BMJ : British Medical Journal·R W Smithells
Sep 17, 1994·BMJ : British Medical Journal·M Kida
Jun 18, 1994·BMJ : British Medical Journal·W G McBride
Jul 10, 1996·Mutation Research·G ZúñigaJ Sánchez-Corona
Aug 15, 1996·Nature·O Flint
Oct 10, 1996·Nature·J Ashby
Apr 28, 1962·Lancet·G S SOMERS
Sep 8, 1962·British Medical Journal·S P WARD
Dec 7, 1963·Nature·F J ROE, B C MITCHLEY
Feb 29, 1964·Nature·G GIACOMELLOG QUAGLIA

❮ Previous
Next ❯

Citations

Feb 8, 2000·Teratology·T D Stephens, B J Fillmore
Sep 19, 2000·Teratogenesis, Carcinogenesis, and Mutagenesis·S TeoS Thomas
Jan 22, 1998·Mutation Research·L R Ferguson, J H Ford
Jan 22, 1998·Mutation Research·J B BishopR A Sloane
Nov 26, 2002·BMJ : British Medical Journal·J Ashby, H Tinwell
Dec 19, 2003·Expert Opinion on Drug Safety·Emmanuel Laffitte, Jean Revuz
Nov 19, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Neil Vargesson
Jun 6, 2015·Birth Defects Research. Part C, Embryo Today : Reviews·Neil Vargesson
Sep 27, 2018·The Journal of Hand Surgery, European Volume·Sahar MansourChristine M Hall
Apr 12, 2001·The Journal of Biological Chemistry·J A KeiferA S Baldwin
May 9, 2000·Biochemical Pharmacology·T D StephensB J Fillmore

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.