Thalidomide therapy of established collagen-induced arthritis (CIA) not accompanied by an evident Th2 shift

Clinical and Experimental Immunology
A HauschildK Zwingenberger

Abstract

Thalidomide, a drug likely to affect the cytokine pattern, was administered orally to mice at various stages of CIA. Treatment (150 mg/kg per day by gavage, 5 days/week), started 6 weeks post-immunization, i.e. at the height of the disease, significantly reduced arthritis, and appeared also to reduce the level of inflammation as judged by neutrophil chemiluminescence. With treatment started 9 weeks post-immunization the effect on arthritis was no longer statistically significant, and when started at 14 weeks was lost. Over a dose range of up to 150 mg/kg per day the treatment had no effect on either interferon-gamma (IFN-gamma) or IL-4 mRNA levels. The treatment is therefore not likely to have operated via a shift in the Th1/Th2 balance.

Citations

Oct 9, 2003·Annals of the Rheumatic Diseases·A E Koch
Jun 17, 2000·Clinics in Dermatology·Y Miyachi
Feb 16, 2005·Expert Opinion on Investigational Drugs·Dahlia T Lainer, Ernest Brahn
Feb 16, 2005·Expert Opinion on Investigational Drugs·K F Chung
Jul 3, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Meital PortugalRon Kohen
Apr 9, 2005·Acta Tropica·Maria Imaculada Muniz-JunqueiraCarlos Eduardo Tosta
Aug 1, 2007·Nature Clinical Practice. Rheumatology·Dahlia Lainer-Carr, Ernest Brahn
Apr 12, 2001·The Journal of Biological Chemistry·J A KeiferA S Baldwin
Nov 14, 2001·Dermatologic Clinics·J R LaDuca, A A Gaspari

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