Thaliporphine, a positive inotropic agent with a negative chronotropic action

European Journal of Pharmacology
M J SuS S Lee

Abstract

The effects of thaliporphine on contractions and electrophysiological properties of cardiac tissues were examined. In driven rat left atria and right ventricular strips, thaliporphine (1-30 microM) increased twitch tension dose-dependently. The positive inotropic effect of thaliporphine was unaffected by atenolol (3 microM) and prazosin (1 microM) but was significantly suppressed by verapamil (1 microM). An electrophysiological study revealed that thaliporphine (3-10 microM) markedly inhibited the action potential upstroke and prolonged the action potential duration (APD50) in rat and guinea pig atrial and ventricular cells. At 1-30 microM, thaliporphine reduced the transient outward current (Ito) of the rat ventricular cells in a dose-dependent manner. The peak Ito in rat ventricular cells and the delayed rectifying K+ current (Ik in guinea pig ventricular cells were reduced by thaliporphine (10 microM) to 37.3 +/- 2.1% (n = 8) and 45.3 +/- 1.8% (n = 4), respectively. In rat ventricular cells and guinea pig atrial cells, thaliporphine (1.5 microM) reduced the Na+ inward current (INa) with a negative shift (4-5 mV) relative to its half inactivation potential. For the Ca2+ inward current (ICa) in rat ventricular cells, 10 microM...Continue Reading

References

Nov 28, 1975·The Journal of Organic Chemistry·M P CavaJ M Saá
Oct 1, 1985·Pflügers Archiv : European journal of physiology·M KameyamaW Trautwein
Mar 1, 1987·Circulation·L M Hondeghem
Dec 1, 1988·Cardiovascular Drugs and Therapy·L H Opie, W A Coetzee
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S Kokubun, H Reuter
Jun 1, 1981·The Journal of Clinical Investigation·R S Williams, T Bishop
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Feb 1, 1984·Circulation Research·I R JosephsonA M Brown
Jan 1, 1984·Acta Academiae Medicinae Wuhan = Wu-han I Hsüeh Yüan Hsüeh Pao·G R LiF H Lü
Jan 1, 2000·Pharmaceutical Biology·I M SetteM S da-Silva

❮ Previous
Next ❯

Citations

Nov 5, 1999·Journal of Biomedical Science·M J SuT S Wu
Nov 5, 1999·Journal of Biomedical Science·C F Huang, M J Su
Jan 18, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Chin-Wei ChiaoMing-Jai Su
Sep 1, 2005·Journal of Biomedical Science·Wei-Luen ChangMing-Jai Su
Feb 24, 2015·BioMed Research International·Gunng-Shinng ChenJia-Yi Wang
Sep 10, 2014·European Journal of Pharmacology·Ching-Chia Chang ChienMing-Jai Su
May 1, 1996·Journal of Cardiovascular Pharmacology·L ChenS S Lee
Aug 1, 1995·Natural Product Reports·K W Bentley
Apr 1, 2016·Journal of Food and Drug Analysis·Hsun-Shuo Chang, Ih-Sheng Chen
Jan 12, 2013·Journal of Natural Products·Chi-Ming ChiouShoei-Sheng Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.