PMID: 7535889Jan 1, 1995Paper

Thallium increases monoamine oxidase activity and serotonin turnover rate in rat brain regions

Neurotoxicology and Teratology
L Osorio-RicoC Ríos

Abstract

The effect of thallium acetate administration on monoaminergic pathways was studied in male Wistar rats using 30 mg/kg and 50 mg/kg acute IP doses. We found that thallium activated both monoamine oxidase (MAO) activity and serotonin turnover rate in rat brain regions, that may contribute to the neuronal damage mechanism of the agent. MAO activity in midbrain and pons was increased at both doses (at 30 mg/kg dose by 27.7% and 37%; at 50 mg/kg dose by 48% and 47%, respectively vs. control group). Serotonin turnover rate in pons was also increased at the 30 mg/kg dose (172%) while midbrain and pons serotonin turnover was increased only at the 50 mg/kg dose (56% and 166%, respectively vs. control group). Dopamine turnover rate was not significantly changed. The results indicate that thallium induced a significant increase in pons and midbrain MAO activity and also in serotonin turnover rate as compared with control animals, and this could led to behavioral and toxic alterations in the rats intoxicated with thallium.

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Citations

Nov 4, 1998·Toxicology Letters·S Galván-Arzate, A Santamaría
Dec 11, 1997·Neurotoxicology and Teratology·J J MejíaM E Jiménez-Capdeville
May 20, 2003·Pharmacology & Toxicology·Laura Osorio-RicoCamilo Ríos
Apr 12, 2007·Journal of Biochemical and Molecular Toxicology·Sergey M KorotkovOlga V Yagodina
Mar 17, 2005·Alcoholism, Clinical and Experimental Research·Matthew J BurdenJoseph L Jacobson
Jul 8, 2005·Doklady. Biochemistry and Biophysics·S M KorotkovO V Iagodina
Sep 4, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·A M VarãoP Gubert

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