PMID: 9535133Apr 16, 1998Paper

Thapsigargin inhibits bicuculline-induced epileptiform excitability in rat hippocampal slices

Neuroscience Letters
E Wülfert, D G Margineanu

Abstract

Evoked field potentials were recorded in the CA3 region of rat hippocampal slices to detect whether intracellular Ca2+ stores are involved in the epileptiform effects of the two prototypic GABA(A) antagonists, bicuculline methiodide (BMI) and gabazine (SR-95531; GBZ). Field population spikes gradually increased and became repetitive (epileptiform bursting) in the presence of either BMI (5 microM), or GBZ (5 microM). Thapsigargin (2 microM), a depletor of intracellular Ca2+ stores, reduced the epileptiform effect of BMI, but had no significant effect on the GBZ-induced hyperexcitability. These data suggest that Ca2+ release from intracellular stores participates in the epileptiform response of hippocampal CA3 neurons to BMI, but not in the response to GBZ.

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Citations

Apr 9, 2002·European Journal of Pharmacology·Yves LambertyHenrik Klitgaard
Feb 2, 2000·Brain Research Bulletin·D G Margineanu, E Wülfert
Mar 19, 2002·Neuropharmacology·P Poulain, D G Margineanu
Nov 1, 2007·Expert Opinion on Drug Discovery·Henrik Klitgaard, Peter Verdru
Feb 25, 2006·Journal of Neuroscience Methods·Olivier DarbinThomas Wichmann
Jan 13, 2005·The Journal of Pharmacology and Experimental Therapeutics·Mauro CataldiLucio Annunziato

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