PMID: 11343837May 10, 2001Paper

The --491 TT apolipoprotein E promoter polymorphism is associated with reduced risk for sporadic Alzheimer's disease

Neuroscience Letters
A Alvarez-ArcayaJ L Fernández-Luna

Abstract

Homozygosity for the A allele of the -491 A/T apolipoprotein E (APOE) promoter polymorphism has recently been reported to be associated with sporadic Alzheimer's disease (AD). Two hundred and fifty one patients with AD and an equal number of controls derived from the same region in a Spanish population, were genotyped for -491 A/T and epsilon2/epsilon3/epsilon4 APOE polymorphisms. We did not detect an elevated -491 AA genotype frequency when comparing AD cases to controls. In contrast, persons homozygous for the T allele were at a significantly reduced risk of AD (odds ratio of 0.10, P=0.006). Multiple logistic regression analysis indicated that the -491 TT polymorphism added information on the risk of AD which was independent of that of the APOE epsilon4 allele.

References

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Citations

Jun 6, 2003·Brain Research Bulletin·A RocchiL Murri
Jan 29, 2009·European Journal of Human Genetics : EJHG·Alessandra BizzarroCarlo Masullo
May 20, 2016·Alzheimer's Research & Therapy·Anna Limon-SztencelJanusz Limon
Oct 31, 2003·The Journal of Biological Chemistry·Faith M HarrisYadong Huang
Aug 16, 2005·Stroke; a Journal of Cerebral Circulation·Daniel WooJoseph Broderick
Nov 22, 2011·Molecular and Cellular Biochemistry·Virginia G BañaresLaura E Schreier

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