The -308 bp TNF gene polymorphism influences tumor necrosis factor expression in leprosy patients in Bahia State, Brazil

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Joyce Moura OliveiraLéa C Castellucci

Abstract

Leprosy or Hansen's disease is a debilitating chronic granulomatous disease caused by Mycobacterium leprae, with high incidence and prevalence in Brazil. The -308 bp G/A single nucleotide polymorphism (SNP rs1800629) in the tumor necrosis factor (TNF) gene promoter is a proposed risk factor for leprosy. In Brazil, Northern India, Egypt and Nepal, the common G allele was associated with leprosy. In Eastern India, Thailand and Malawi the minor A allele was the risk factor. Allele A was previously associated with high TNF. We genotyped rs1800629 in 326 leprosy cases from Bahia State, Brazil, including 72 paucibacillary (PB) and 47 multibacillary (MB) without reactions, and 69 reversal reaction (RR) and 78 erythema nodosum leprosum (ENL) with reactions. Logistic regression was used to compare patient groups with 331 healthy controls. Relative TNF mRNA was determined in peripheral blood leukocytes by QRTPCR, and serum TNF levels measured by ELISA. We found that TNF mRNA expression was higher (P=0.03) in leprosy patients compared to endemic controls, but did not differ significantly between clinical subgroups. Carriage of the minor A allele was associated (P=0.003) with low TNF mRNA across leprosy patients. Nevertheless, we found no ...Continue Reading

References

Feb 11, 2003·Nature Genetics·Marcelo T MiraErwin Schurr
Jan 23, 2004·Nature·Marcelo T MiraErwin Schurr
Feb 20, 2004·Genes and Immunity·J-P BayleyC L Verweij
Feb 6, 2008·Human Genetics·Andrea AlterErwin Schurr
Dec 9, 2008·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Danilo Santana Alessio FranceschiJeane Eliete Laguila Visentainer
Apr 16, 2009·Clinical Microbiology Reviews·Jenefer M BlackwellDavid Burgner
Dec 19, 2009·The New England Journal of Medicine·Fu-Ren ZhangJian-Jun Liu
Dec 26, 2009·Bioorganic & Medicinal Chemistry·Scott G StewartLawrence J Abraham
Jul 24, 2010·Human Immunology·Bishwa R SapkotaThomas R Hawn
Oct 12, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Andrea AlterErwin Schurr
Jul 28, 2011·Scandinavian Journal of Immunology·T Qidwai, F Khan
Dec 20, 2011·PLoS Neglected Tropical Diseases·Diana N J LockwoodSujai Suneetha
May 1, 2012·Seminars in Arthritis and Rheumatism·Pablo LluchJuan D Cañete
Nov 16, 2012·Revista Da Sociedade Brasileira De Medicina Tropical·Ana Amélia Lucena CavalcantiPatrícia Maria Cavalcanti Carneiro de Albuquerque
Aug 13, 2015·PLoS Neglected Tropical Diseases·Paulo R L MachadoMarshall J Glesby
Sep 24, 2015·European Journal of Human Genetics : EJHG·Hadassa C SantosUNKNOWN Brazilian EPIGEN Project Consortium

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