The -374T/A variant of the rage gene promoter is associated with clinical restenosis after coronary stent placement

International Journal of Immunopathology and Pharmacology
Colomba FalconeMariaclara Cuccia

Abstract

Upregulation of the receptor for advanced glycation end products (RAGE) may play a crucial role in neointimal formation upon vessel injury. The -374T/A variant of the RAGE gene promoter, which has been associated with an altered expression of the cell-surface receptor, could exert a protective effect toward the development of vascular disease. The aim of this study is to determine the impact of this common genetic variant in the occurrence of clinical in-stent restenosis after coronary stent implantation. The -374T/A polymorphism of the RAGE gene promoter was evaluated by PCR-RFLPs in 267 patients with coronary artery disease who underwent coronary stent implantation and a subsequent coronary angiography 6-9 months later for suspected restenosis. In-stent restenosis was assessed by means of quantitative angiography. Carriers of the -374AA genotype showed a significantly reduced risk of developing restenosis after percutaneous transluminal intervention than non-carriers. To determine whether the protective effect of the homozygous AA genotype toward clinical restenosis was independent of potential confounders, we performed multivariable logistic regression analysis. After allowance for clinical and biochemical risk factors and s...Continue Reading

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Citations

Jan 7, 2011·Rejuvenation Research·Chiara BoiocchiColomba Falcone
Mar 27, 2013·International Journal of Immunopathology and Pharmacology·C FalconeG Pelissero
Nov 29, 2013·International Journal of Molecular Sciences·Colomba FalconeGabriele Pelissero
Jul 23, 2013·International Journal of Immunogenetics·Elisa MaggioliMariaclara Cuccia
Mar 12, 2009·Clinical Science·Anastasia Z KaleaBarry I Hudson

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