The -759C/T polymorphism of the 5-HT2C receptor is associated with type 2 diabetes in male and female Caucasians

Pharmacogenetics and Genomics
Maria IordanidouVangelis G Manolopoulos

Abstract

Type 2 diabetes mellitus and obesity constitute serious health problems. Studies reveal that the 5-HT2C receptor contributes substantially to the regulation of a wide variety of behavioral and physiological processes including feeding and glucose homeostasis. Our aim was to determine the possible association of the -759C/T polymorphism of the 5-HT2C receptor gene with type 2 diabetes and obesity in male and female individuals Caucasian origin. The study population consisted of 151 patients diagnosed with type 2 diabetes and 164 nondiabetic patients, all of Greek origin. Genomic DNA was extracted from peripheral blood and analyzed for the -759C/T polymorphism of the 5-HT2C receptor gene using polymerase chain reaction-restriction fragment length polymorphism method. The frequency of T allele of the -759C/T polymorphism of the 5-HT2C receptor was significantly lower in the diabetic group (12.6%) than in the nondiabetic group (23.3%) (P=0.003). The genetic risk of type 2 diabetes for patients not carrying the T allele was increased compared with nondiabetic patients (odds ratio (OR)=2.34, 95% confidence interval (CI)=1.36-4.02). The reduced frequency of T allele was present both in male [10% in patients with diabetes and 21.6% in ...Continue Reading

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Citations

Nov 30, 2011·The Journal of Biological Chemistry·Hao WangGuoqing Sheng
Jan 12, 2010·Drug and Alcohol Dependence·Maria IordanidouVangelis G Manolopoulos
Nov 7, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Maria IordanidouVangelis G Manolopoulos
May 18, 2012·Diabetes Research and Clinical Practice·Georgia RagiaVangelis G Manolopoulos
Mar 13, 2010·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Georgia RagiaVangelis G Manolopoulos
Oct 5, 2017·Archives of Endocrinology and Metabolism·Noa Pereira Prada SchnorMaria Rita Marques de Oliveira
Aug 10, 2021·Frontiers in Endocrinology·Ting YaoTiemin Liu

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