The -A162G polymorphism of the PON1 gene and the risk of sporadic amyotrophic lateral sclerosis

Neurologia i neurochirurgia polska
Dorota ZawiślakAgnieszka Słowik

Abstract

Sporadic amyotrophic lateral sclerosis (sALS) is a devastating neurodegenerative disease, which results from complex genetic and environmental interactions. Recent studies have reported an association between several polymorphisms of the PON1 and PON2 genes and risk of sALS. The aim of the present study was to identify an association between the -A162G polymorphism of the promoter region of the human PON1 gene and the risk of sALS in a Polish population. We included 259 patients with a diagnosis of definite or probable sALS (76 bulbar onset, 183 limb onset) and 694 healthy controls matched for age and sex. The diagnosis of ALS was established according to El Escorial criteria. The polymorphism was studied by Single Nucleotide Polymorphism Real-Time Polymerase Chain Reaction analysis. No overall difference in the PON1 -A162G geno-type and allele distribution was seen between cases and controls (all p > 0.05). There was, however, a difference in the A allele frequency when the bulbar onset group was compared to the controls (p = 0.03), but this significance disappeared after the Bonferroni correction. The results did not show that the -A162G polymorphism of the PON1 gene is a risk factor of sALS in a Polish population; it may aff...Continue Reading

References

Feb 24, 2001·Pharmacogenetics·V H BrophyC E Furlong
May 4, 2001·American Journal of Human Genetics·V H BrophyC E Furlong
Jun 2, 2001·The New England Journal of Medicine·L P Rowland, N A Shneider
Jul 24, 2001·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·B R BrooksUNKNOWN World Federation of Neurology Research Group on Motor Neuron Diseases
Jun 5, 2003·Pharmacology & Therapeutics·Michael J Strong
Sep 25, 2003·Neurology·Robert W Haley
Oct 11, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Hong-Liang LiChih-Chuan Liang
Jan 7, 2005·Brain : a Journal of Neurology·Adriano ChiòGabriele Mora
Dec 2, 2005·Human Molecular Genetics·Porat M ErlichUNKNOWN MIRAGE Study Group
Jul 11, 2006·Neurology·A SlowikD A Figlewicz
Apr 19, 2007·Brain : a Journal of Neurology·Dalia KasperaviciuteElizabeth M C Fisher
Aug 3, 2007·The New England Journal of Medicine·Travis DunckleyDietrich A Stephan
Aug 21, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Simon CroninOrla Hardiman
Jul 12, 2008·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·John E LandersRobert H Brown
Feb 5, 2009·Orphanet Journal of Rare Diseases·Lokesh C Wijesekera, P Nigel Leigh
Mar 12, 2009·The Neurologist·Catherine A Kernich

❮ Previous
Next ❯

Citations

Mar 15, 2013·Neurologia i neurochirurgia polska·Beata Zakrzewska-PniewskaAndrzej Szczudlik
Jan 16, 2013·Neurologia i neurochirurgia polska·Bogusław MachalińskiPrzemysław Nowacki
Jun 26, 2013·Free Radical Biology & Medicine·Emanuele D'AmicoHiroshi Mitsumoto
Jul 16, 2011·Dementia and Geriatric Cognitive Disorders·A Klimkowicz-MrowiecA Slowik
Apr 20, 2012·The Cochrane Database of Systematic Reviews·Reto BaldingerMarkus Weber

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

Related Papers

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
X HeY Xu
© 2021 Meta ULC. All rights reserved