The γ-aminobutyric acid type B (GABAB) receptor agonist baclofen inhibits morphine sensitization by decreasing the dopamine level in rat nucleus accumbens.

Behavioral and Brain Functions : BBF
Zhenyu FuHaiyan Huang

Abstract

Repeated morphine exposure can induce behavioral sensitization. There are evidences have shown that central gamma-aminobutyric acid (GABA) system is involved in morphine dependence. However, the effect of a GABAB receptor agonist baclofen on morphine-induced behavioral sensitization in rats is unclear. We used morphine-induced behavioral sensitization model in rat to investigate the effects of baclofen on behavioral sensitization. Moreover, dopamine release in the shell of the nucleus accumbens was evaluated using microdialysis assay in vivo. The present study demonstrated that morphine challenge (3 mg/kg, s.c.) obviously enhanced the locomotor activity following 4-day consecutive morphine administration and 3-day withdrawal period, which indicated the expression of morphine sensitization. In addition, chronic treatment with baclofen (2.5, 5 mg/kg) significantly inhibited the development of morphine sensitization. It was also found that morphine challenge 3 days after repeated morphine administration produced a significant increase of extracellular dopamine release in nucleus accumbens. Furthermore, chronic treatment with baclofen decreased the dopamine release induced by morphine challenge. Our results indicated that gamma-ami...Continue Reading

References

Sep 1, 1993·Brain Research. Brain Research Reviews·T E Robinson, K C Berridge
May 19, 1998·Journal of Psychopharmacology·P W KalivasB A Sorg
Apr 24, 2001·Pharmacology & Therapeutics·M NaritaT Suzuki
May 16, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·S H WooC G Jang
Nov 12, 2003·The Journal of Pharmacology and Experimental Therapeutics·Kimberly A Leite-MorrisGary B Kaplan
Apr 6, 2004·Trends in Pharmacological Sciences·Eric J Nestler
Jun 16, 2004·Behavioural Brain Research·Jun-Xu LiJian-Hui Liang
Aug 13, 2004·Brain Research·Jun-Xu LiJian-Hui Liang
Dec 8, 2004·Brain Research. Molecular Brain Research·Colleen A McClungEric J Nestler
Aug 16, 2005·Neuroscience and Biobehavioral Reviews·R Christopher Pierce, Vidhya Kumaresan
Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·John McDaidT Celeste Napier
Dec 22, 2005·Addiction·Rainer Spanagel, Markus Heilig
Jan 13, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Margaret HaneyRichard W Foltin
Jan 24, 2007·Psychopharmacology·Maria BartolettiMargherita Gaiardi
Jun 7, 2007·Behavioural Pharmacology·Mohammad-Reza ZarrindastAkbar Hajizadeh-Moghaddam
Jul 3, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Xiao-Li WeiJin Li
Oct 3, 2007·Alcoholism, Clinical and Experimental Research·Darin J KnappGeorge R Breese
Aug 16, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·V I Chefer, T S Shippenberg
Nov 11, 2008·Annals of the New York Academy of Sciences·Minoru NaritaTsutomu Suzuki
Mar 3, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Liana FattorePaola Fadda
May 1, 2009·The Journal of Pharmacology and Experimental Therapeutics·Mark A SmithJennifer N Felder
May 13, 2009·Pharmacopsychiatry·P Dayan
Jul 2, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michel C Van den OeverSabine Spijker
Jul 27, 2010·Advances in Pharmacology·Robin J TyackeDavid J Nutt
Aug 3, 2010·Neurochemistry International·Jun-ichi KarasawaShigeyuki Chaki
Sep 3, 2010·Pharmacology, Biochemistry, and Behavior·Maria BartolettiMargherita Gaiardi
Oct 22, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anuradha MadhavanJennifer L Whistler
Dec 17, 2010·Current Topics in Behavioral Neurosciences·Ingo WilluhnPaul E M Phillips

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Citations

Sep 30, 2014·Peptides·Richard J Bodnar
Mar 19, 2013·Pharmacology, Biochemistry, and Behavior·T J R BeveridgeL J Porrino
Apr 19, 2017·Behavioral and Brain Functions : BBF·Nan WuTao Sun
Sep 18, 2014·The European Journal of Neuroscience·Kimberley A PitmanStephanie L Borgland
Jun 27, 2019·The Journal of Pharmacology and Experimental Therapeutics·Jenny L WilkersonLance R McMahon

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