The 1-hour post-load glucose level is more effective than HbA1c for screening dysglycemia

Acta Diabetologica
Ram JagannathanMichael Bergman

Abstract

To assess the performance of HbA1c and the 1-h plasma glucose (PG ≥ 155 mg/dl; 8.6 mmol/l) in identifying dysglycemia based on the oral glucose tolerance test (OGTT) from a real-world clinical care setting. This was a diagnostic test accuracy study. For this analysis, we tested the HbA1c diagnostic criteria advocated by the American Diabetes Association (ADA 5.7-6.4 %) and International Expert Committee (IEC 6.0-6.4 %) against conventional OGTT criteria. We also tested the utility of 1-h PG ≥ mg/dl; 8.6 mmol/l. Prediabetes was defined according to ADA-OGTT guidelines. Spearman correlation tests were used to determine the relationships between HbA1c, 1-h PG with fasting, 2-h PG and indices of insulin sensitivity and β-cell function. The levels of agreement between diagnostic methods were ascertained using Cohen's kappa coefficient (Κ). Receiver operating characteristic (ROC) curve was used to analyze the performance of the HbA1c and 1-h PG test in identifying prediabetes considering OGTT as reference diagnostic criteria. The diagnostic properties of different HbA1c thresholds were contrasted by determining sensitivity, specificity and likelihood ratios (LR). Of the 212 high-risk individuals, 70 (33 %) were identified with predia...Continue Reading

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Citations

Sep 2, 2016·Diabetes Research and Clinical Practice·Djordje S Popovic, Stefano Del Prato
Dec 18, 2016·Diabetes & Metabolic Syndrome·Martin BuysschaertVanessa Preumont
Feb 1, 2018·Acta Diabetologica·Ram JagannathanMichael Bergman
Jul 19, 2018·The Journal of Clinical Endocrinology and Metabolism·Teresa Vanessa FiorentinoGiorgio Sesti
Nov 18, 2018·The Journal of Clinical Endocrinology and Metabolism·Gopal PeddintiLeif Groop
Oct 4, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Brian J MartinMartin J Gibala
Jun 12, 2020·The Journal of Clinical Endocrinology and Metabolism·Michael BergmanMartin Buysschaert
Feb 15, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jeffrey I MechanickW Timothy Garvey
Mar 4, 2019·Acta Diabetologica·Aldo Bonaventura, Fabrizio Montecucco
May 28, 2019·Nutrition & Diabetes·Lien HaveralsLuc Van Gaal
Jul 2, 2019·Annals of Pediatric Endocrinology & Metabolism·Preneet Cheema Brar
Apr 30, 2017·Diabetic Medicine : a Journal of the British Diabetic Association·R Jagannathan, M Bergman
Oct 30, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Ram JagannathanMichael Bergman

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