PMID: 7435413Nov 1, 1980

The 1-hr blood xylose test in the evaluation of malabsorption in infants and children

The American Journal of Clinical Nutrition
J R Kraut, J D Lloyd-Still


One hundred ninety-seven 1-hr blood xylose absorption tests with 5 g of D-xylose were performed on 171 infants and children for the evaluation of malabsorption. The mean +/- 1 SD blood xylose level in 78 controls was 37.0 +/- 7.7 mg/dl, and 71 patients with post infectious diarrhea was 28.4 +/- 11.0 mg/dl. A significant reduction (P < 0.001) was found in 10 patients with Celiac disease (12.0 +/- 8.6 mg/dl) and 18 patients with intractable diarrhea syndromes (18.3 +/- 12.5 mg/dl). Forty-four patients had a blood xylose level less than 20 mg/dl, and the majority (35/44) were in the groups with postinfection and intractable diarrhea syndromes. Multiple tests were performed on 20 patients. Sixty-two intestinal biopsies were correlated with 1-hr blood xylose levels. The rate of false positives was 0. The rate of false negative tests varied between 4 to 32.7% depending on the assessment of intestinal damage. Our results confirm that the 1-hr blood xylose absorption test is a sensitive indicator of severe intestinal damage. Intestinal biopsy should be considered in all patients with a 1-hr blood xylose level less than 20 mg/dl. With borderline results (20 to 25 mg/dl), clinical decisions must be individualized.

Related Concepts

Dose-Response Relationship, Drug
Structure of Intestinal Gland
Intestines, Small
Malabsorption Syndrome

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

© 2021 Meta ULC. All rights reserved