PMID: 22361887Mar 1, 2012Paper

The 129 genetic background affects susceptibility to glomerulosclerosis in tensin2-deficient mice

Biomedical Research
Tomohiro NishinoTakashi Agui

Abstract

The ICGN mouse strain is a glomerulosclerosis (GS) model that shows significant proteinuria, podocyte morphological abnormalities and increased extracellular matrix accumulation in the glomeruli, which represent the final common pathology associated with a variety of kidney diseases leading to end-stage renal failure. Previously, we demonstrated that GS in ICGN mice can be attributed to the deletion mutation of the tensin2 (Tns2) gene (Tns2(nep)). Further, the C57BL/6J (B6) mouse is resistant to GS caused by this mutation. 129/Sv is also a popular strain; however, its susceptibility to GS has not been defined. Thus, to determine whether 129/Sv is resistant or susceptible to GS, we produced a congenic strain carrying Tns2(nep) on the 129(+Ter)/Sv (129T) background. 129T congenic mice (129T-Tns2(nep)) did not exhibit albuminuria, renal anemia, increases in BUN, or any severe pathological changes until at least 16 weeks of age. These results indicate that 129T is resistant to GS. Although their usage in biomedical studies is already widespread, 129/Sv mice may afford a late-onset and unique strain applicable to kidney disease research.

References

Jun 1, 1991·The Journal of Veterinary Medical Science·A OguraH Fujimura
Apr 22, 2003·Seminars in Nephrology·Martin R Pollak
Apr 22, 2003·Seminars in Nephrology·Agnes B Fogo
Jun 5, 2003·European Journal of Immunology·Katrin SchwarzMartin F Bachmann
Jun 5, 2003·The Journal of Clinical Investigation·Claudine H KosMartin R Pollak
Jan 1, 2004·Molecular and Cellular Biology·Séverine RoselliCorinne Antignac
Feb 14, 2004·Immunological Reviews·Antonius G RolinkFritz Melchers
May 12, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·A-Ri ChoTakashi Agui
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Timothy J BaulerPhilip D King
May 21, 2010·The Journal of Veterinary Medical Science·Tomohiro NishinoTakashi Agui

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Citations

May 19, 2018·Nature Communications·Shazia AshrafFriedhelm Hildebrandt
Feb 9, 2016·The Journal of Veterinary Medical Science·Kozue Uchio-YamadaNoboru Manabe

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